Evaluation of antimicrobial photodynamic therapy on wounds infected by Staphylococcus aureus in animal models.

Photodiagnosis and Photodynamic Therapy
Sepehr TorabiReza Fekrazad

Abstract

Antibiotic-resistant Staphylococcus aureus bacteria are one of the expanding challenges. The purpose of current study is to evaluate the antimicrobial effect of photodynamic therapy (aPDT) on wounds infected to Staphylococcus aureus. In this study, 40 six-month-old rats were divided into 4 groups: control, photosensitizer (PS), laser, and aPDT. A full-thickness wound was created on their skin and it was infected by Staphylococcus aureus. For aPDT, the Indocyanine Green (Germany, Nürnberg, A.R.C. Laser, EmunDo) photosensitive agent and laser diod 810 nm (Germany, Nürnberg, A.R.C. Laser) was utilized. The wound healing procedure was monitored every 24 h until the 12th day with photography. The number of the bacteria was counted on the 12th day also. All results were compared using ANOVA and Tukey post hoc tests. Significance level was considered P-Value < 0.05. The average area of wound reduced in days 5-11th in photosensitizer, laser, and aPDT, respectively. The absolute colonization rate of bacteria in the wounds showed a significant decrease in two groups laser and aPDT compared to the control group. However, the lowest value was for the aPDT. In the conditions of this study, it emerged that aPDT and laser have an antimicrobia...Continue Reading

References

Jan 1, 1992·Photochemistry and Photobiology·Y NitzanB Ehrenberg
Sep 17, 1999·Journal of Clinical Microbiology·M F VandenBerghH A Verbrugh
Sep 2, 2003·Journal of Bacteriology·Yuki KatayamaHenry F Chambers
May 4, 2004·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Michael Wilson
May 4, 2004·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Faten GadMichael R Hamblin
Feb 25, 2005·Antimicrobial Agents and Chemotherapy·Tak-Wah WongYin-Ching Chuang
Nov 5, 2008·Journal of Periodontology·Juliano Milanezi de AlmeidaValdir Gouveia Garcia
Feb 6, 2009·BMC Microbiology·Parjam S ZolfaghariMichael Wilson
Feb 25, 2009·Journal of Clinical Periodontology·Leandro Araújo FernandesValdir Gouveia Garcia
Jan 16, 2010·Lasers in Surgery and Medicine·Tianhong DaiMichael R Hamblin
Jan 22, 2010·Journal of Clinical Microbiology·Ehsanollah Ghaznavi-RadVasanthakumari Neela
Sep 29, 2011·Photochemistry and Photobiology·Masamitsu TanakaYuji Morimoto
Sep 4, 2012·Journal of Chiropractic Medicine·Bart N GreenMarion Willard Evans
Oct 10, 2012·Current Opinion in Microbiology·José R MediavillaBarry N Kreiswirth
Apr 5, 2013·Recent Patents on Anti-infective Drug Discovery·Felipe F SperandioMichael R Hamblin
May 27, 2014·Lasers in Medical Science·Reza FekrazadMohammad-Mehdi Dehghan
Feb 19, 2015·Journal of Biomedical Optics·Nermin TopalogluMurat Gülsoy
Sep 14, 2018·Clinical Microbiology Reviews·Sahreena Lakhundi, Kunyan Zhang
Mar 24, 2020·Journal of Photochemistry and Photobiology. B, Biology·Juliana Rodrigues de CastroAlyne Simões

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology
Lisa KarnerPeter Dungel
© 2021 Meta ULC. All rights reserved