Evaluation of antioxidant activity of Salix caprea flowers

Phytotherapy Research : PTR
M Sarwar AlamM Athar

Abstract

The study was aimed at evaluating the antioxidant activity of an ethanol extract of Salix caprea L. (Salicaceae) flowers. The extract was found to possess a large amount of polyphenols and also exhibited a high reducing ability. The extract significantly and dose dependently scavenged DPPH, superoxide (O(2) (*-)), hydrogen peroxide (H(2)O(2)) and nitric oxide (NO). At a concentration of 250 microg/mL, 85.04% of DPPH radicals and at 500 microg/mL 45.97%, 17.97% and 56.53% of O(2) (*-), H(2)O(2) and NO, respectively, were scavenged by the S. caprea flower extract. A significant amount of protection was also afforded by the extract in the acute oxidative tissue injury animal model constituted by ferric nitrilotriacetate (FeNTA) induced hepatotoxicity in mice. An intraperitoneal administration of FeNTA at a dose of 9 mg/kg of body weight caused an elevation in hepatic lipid peroxidation (LPO) to 176.90% and a suppression in hepatic glutathione (GSH) content and the activities of antioxidant enzymes namely, catalase (CAT), glutathione reductase (GR) and glutathione peroxidase (GPX) to 46.49%, 64.37%, 41.71% and 48.76%, respectively, of the saline treated control. The pretreatment of mice with S. caprea flower extract at a dose range...Continue Reading

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Citations

Apr 4, 2014·TheScientificWorldJournal·Urszula Gawlik-DzikiPiotr Sugier
Sep 4, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mina LeeSang Hyun Sung
Sep 17, 2015·Journal of Ethnopharmacology·Snežana JarićPavle Pavlović
Jul 31, 2016·BMC Complementary and Alternative Medicine·Ahmed WahidMekky M Abouzied
May 23, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Irshad A LoneM Sarwar Alam
Oct 11, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Shikha SharmaDeepak Sharma
Nov 16, 2017·Scientific Reports·Jessica L MetcalfLudovic Orlando
Mar 2, 2021·Frontiers in Pharmacology·Nora TawfeekAssem M El-Shazly

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