Evaluation of antioxidant and immunity function of tetramethylpyrazine phosphate tablets in vivo.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Ling GuoChongen Xu

Abstract

The aim of the study was to determine the effect of tetramethylpyrazine phosphate tablets (TPT), a Chinese medicine used for cardiovascular disease, on immunity activity and oxidative injury in rats. Heart failure (HF) was induced by isoproterenol (ISO). After the animal model was established, the rats were administered the TPT by gavage (once a day). The results indicated that TPT improved left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), ±dP/dt, heart weight/body weight. TPT could decrease the levels of tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6). Furthermore, it also could raise the activities of catalase, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), but reduce malonyldialdehyde (MDA) level. The results indicated that TPT improved cardiac function and myocardial fibrosis from myocardial injury, and this cardioprotection might be attributed to a reduction of oxidative stress and regulation of inflammation mediators.

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Citations

Apr 23, 2013·Luminescence : the Journal of Biological and Chemical Luminescence·Li ShuaiTianming Yang
May 30, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Qian-Qian LiangYong-Jun Wang
Aug 2, 2016·Biological & Pharmaceutical Bulletin·Xin CaoAtsushi Sugiyama

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