Evaluation of Antiproliferative Activity, Safety and Biodistribution of Oxaliplatin and 5-Fluorouracil Loaded Lactoferrin Nanoparticles for the Management of Colon Adenocarcinoma: an In Vitro and an In Vivo Study

Pharmaceutical Research
Farhan AhmedAnand K Kondapi

Abstract

Colon adenocarcinoma is the most common form of gastro intestinal tract cancer, predominantly in ageing population. Chemotherapy with 5-Fluorouracil and oxaliplatin is an indispensable treatment regimen, nevertheless having limitation of systemic toxicity and lower therapeutic index. The present study is based on evaluation of anti-proliferative potential, pharmacokinetics parameters, safety profile, biodistribution and efficacy of 5-FU/oxaliplatin loaded lactoferrin nanoparticles in cell lines and wistar rats in order to overcome the above limitation. Nanoparticles were prepared by Water-in-oil process. The anti-proliferative efficacy and mode of cellular entry was evaluated in COLO-205 cells. The pharmacokinetics and biodistribution analysis were performed in healthy rats while efficacy and safety assay were performed in ACF induced rats. 5-FU and oxaliplatin loaded nanoparticles shows enhanced antiproliferative activity as compare to free drugs in COLO-205 cells. Lactoferrin nanoparticles also improve the pharmacokinetics profile, safety parameters and efficacy of 5-FU and Oxaliplatin. Lactoferrin nanoparticles demonstrated an attractive drug delivery module to manage the colon adenocarcinoma as it has improved the antiproli...Continue Reading

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Citations

Aug 4, 2020·Chemical & Pharmaceutical Bulletin·Kazuaki TaguchiKeishi Yamasaki
Mar 5, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jiao ZhengShufang Chang
May 7, 2020·Asian Journal of Pharmaceutical Sciences·Yi PengLushan Yu
Aug 4, 2021·Parasitology Research·Mohaddeseh Abouhosseini TabariMohammad Reza Youssefi
Nov 17, 2021·Investigative Ophthalmology & Visual Science·Revu V L NarayanaGeeta K Vemuganti

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Methods Mentioned

BETA
surgical resection
scanning
transmission
Dynamic light scattering
electron microscopy
confocal microscopy
Assay
ELISA
transmission electron microscopy
Dynamic

Software Mentioned

Kinetica

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