Evaluation of antipruritic effects of several agents on scratching behavior by NC/Nga mice

European Journal of Pharmacology
N TakanoMichio Kurachi

Abstract

We investigated the effects of several agents on the established itching model in NC/Nga mice, model of atopic dermatitis-like disease, to elucidate related characteristics. The number of spontaneous scratching behaviors (the duration time is over 1.5 s) by NC/Nga mice with severe skin lesions was measured before and after administration of agents for 24 h. The scratching behavior by NC/Nga mice was significantly suppressed by administration of dexamethasone or tacrolimus, but not by chlorpheniramine maleate or cyproheptadine hydrochloride. These results suggest that this method shows a good correlation with the effectiveness of drugs prescribed for itching in humans with atopic dermatitis, and histamine and serotonin do not play an important role in causing the scratching behavior seen by NC/Nga mice. The scratching behavior was also significantly suppressed by naloxone hydrochloride, dibucaine or capsaicin. These results suggest that the scratching behavior seen in this model is caused by itching signal transmission through neural system. Furthermore, we found that theophylline, pinacidil or limaprost had scratching suppression effects in this model.

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Citations

Jun 1, 2005·European Journal of Pharmacology·Akiko TakaokaShiro Nakaike
Aug 30, 2008·Cornea·Nobuyuki EbiharaChisei Ra
Oct 13, 2009·European Journal of Pharmacology·Naoki InagakiHiroichi Nagai
Nov 10, 2009·Journal of Dermatological Science·Satoshi TakeuchiStephen I Katz
Oct 20, 2005·Experimental Dermatology·N TakahashiS Nakaike
Jan 8, 2008·Experimental Dermatology·Klas NordlindAndrzej Slominski
Feb 17, 2006·Experimental Dermatology·A TakaokaS Nakaike
Jul 18, 2006·Experimental Dermatology·Masanori SugimotoShiro Nakaike
Jan 13, 2015·Immunopharmacology and Immunotoxicology·Tasuku NakasoneChiaki Kamei
Nov 9, 2005·Journal of Pharmacological Sciences·Norikazu TakanoMichio Kurachi
Sep 21, 2016·The Journal of Medical Investigation : JMI·Shinya YoshidaToshiyuki Watanabe
Sep 4, 2018·European Journal of Pain : EJP·Minoru TsujiSaburo Saito
Feb 2, 2006·International Archives of Allergy and Immunology·Dimitrios KalogeromitrosTheoharis C Theoharides
May 16, 2013·The Journal of Pharmacology and Experimental Therapeutics·Naoto IshiiIeharu Hishinuma
Sep 17, 2005·International Journal of Immunopathology and Pharmacology·D KalogeromitrosT C Theoharides
Jun 13, 2017·Experimental Dermatology·Gema TarrasónNúria Godessart
Dec 15, 2006·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Iwao Arai

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