PMID: 2507122Oct 15, 1989Paper

Evaluation of antitumor activity in a human breast tumor/nude mouse model with a special emphasis on treatment dose

Cancer
M InabaT Nomura

Abstract

Eight lines of human breast tumors implanted in nude mice were treated with various antitumor agents at two different doses, maximum tolerated doses (MTD) and rational doses (RD) that were pharmacokinetically equivalent to the clinical doses; the response rates to both doses were compared. With MTD, the response rates to mitomycin C and vinblastine were 100%, and those to other agents including cyclophosphamide, nimustine (a water-soluble nitrosourea), vincristine, Adriamycin (doxorubicin; Adria Laboratories, Columbus, OH), 5-fluorouracil (5-FU), and methotrexate were 30%-50%, indicating high responsiveness to the former two agents. In contrast, when the RD were used, the response rates to the majority of these agents were 25%-40%, and those to vincristine and nimustine were 13% and 0%, respectively. These results agree with the reported clinical results compared with those with MTD, suggesting the importance of the use of clinically equivalent doses in the evaluation of antitumor efficacy in a human tumor/nude mouse system.

References

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Citations

Jan 1, 1990·Cancer Chemotherapy and Pharmacology·Y MitsuhashiT Kobayashi
Oct 1, 2013·The Breast : Official Journal of the European Society of Mastology·Robert S KerbelShan Man
Mar 1, 1997·Bioorganic & Medicinal Chemistry·S NagamuraH Saito
Jun 10, 2010·Nature Biotechnology·Giulio Francia, Robert S Kerbel
Jun 2, 2004·Nature Reviews. Cancer·Robert S Kerbel, Barton A Kamen
Dec 10, 1997·Journal of the National Cancer Institute·M MiyazakiP Armatis
Jul 21, 1999·Journal of the National Cancer Institute·M AghiX O Breakefield
Nov 11, 2008·Biomedical Research·Chiyoko NishimeHiroshi Kijima
Sep 24, 2015·Expert Opinion on Therapeutic Patents·Ping-Shan LaiPatrick T Gunning
Jan 30, 2004·International Journal of Cancer. Journal International Du Cancer·Yu-suke TorisawaTomokazu Matsue
Oct 4, 2005·The Breast : Official Journal of the European Society of Mastology·Raquel MunozRobert S Kerbel
Nov 14, 2008·Clinical Pharmacology and Therapeutics·B Rubio-Viqueira, M Hidalgo
Jul 7, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R S KerbelJ Rak
Aug 25, 2004·Cancer Treatment Reviews·F Y F L de VosJ A Gietema
Oct 31, 2021·Clinical and Translational Science·James W T Yates, David A Fairman

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