PMID: 25735382Mar 5, 2015Paper

Evaluation of antitumor and antioxidant activity of Sargassum tenerrimum against Ehrlich ascites carcinoma in mice

Asian Pacific Journal of Cancer Prevention : APJCP
Satyajit PatraSujitha Parthiban

Abstract

In the last half century, discovering, developing and introducing of clinical agents from marine sources have seen great successes, with examples including the anti-cancer compound trabectedin. However, with increasing need for new anticancer drugs, further exploration for novel compounds from marine organism sources is strongly justified. The major aim of this study was to evaluate the antitumor and antioxidant potential of Sargassum tenerrimum J.Agardh (Sargassaceae) on Ehrlich ascites carcinoma (EAC) in Swiss albino mice. An ethanol extract of S. tenerrimum (EEST) from whole algae was used to evaluate cytotoxicity followed by in vivo assessment of toxicity, using biochemical parameters including hepatic and non-hepatic enzymes. Antioxidant properties were examined in animals bearing EAC treated with daily oral administration of 100-300 mg/kg extract suspension. Antitumor effects of EEST in EAC bearing mice was observed with LD50 1815 mg/kg. Parameters like body weight, tumor volume, packed cell volume, tumor cell count, mean survival time and increase in life span in animals in the EAC bearing animals treated with EEST 300 mg/kg was comparable with control group. Significant differences were also seen with changes in total p...Continue Reading

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Citations

Aug 2, 2018·BMC Research Notes·Ed Carlos Rey MouraRioko Kimiko Sakata
Apr 10, 2019·Anti-cancer Agents in Medicinal Chemistry·Waad A Al-OtaibiAbdulwahab N Wali
Apr 3, 2019·Molecular Biology Reports·Monira M Rageh, Reem H El-Gebaly
Feb 17, 2017·International Journal of Molecular Medicine·In-Hye Kim, Taek-Jeong Nam

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