Evaluation of antivenom therapy in Vipera palaestinae bites

Toxicon : Official Journal of the International Society on Toxinology
Yedidia BenturMaya Galperin

Abstract

Vipera palaestinae antivenom has been successfully used to treat systemic and progressive local manifestations inflicted by this snake. The clinical course of several envenomations created the impression that the recommended fixed dose regimen of antivenom (50 ml) may not always be sufficient. To evaluate the V. palaestinae antivenom fixed dose regimen and to assess the need for repeated antivenom administration as well as possible adverse effects. Retrospective review of prospectively collected poison center data over a one-year period. One hundred and twelve patients were evaluated, 48% of whom were treated with antivenom. Antivenom treatment resulted in complete disappearance of systemic manifestations with no relapse. Three patients required additional doses of antivenom for marked progressive local signs--one initially received 50 ml of antivenom and two others only 30 ml. Anaphylaxis and serum sickness were each observed in 3.7% of the treated patients. The fixed dose regimen of 50 ml V. palaestinae antivenom is efficacious for the treatment of systemic and progressive local manifestations caused by this snake. There is insufficient data on whether smaller doses can be successfully used for systemic manifestations and whe...Continue Reading

References

Mar 1, 1996·Annals of Emergency Medicine·R C DartJ Boren
Jan 14, 1998·Human & Experimental Toxicology·G ParetZ Barzilay
Jul 15, 1998·Toxicon : Official Journal of the International Society on Toxinology·I Y ShemeshA Bourvin
Apr 5, 2003·Toxicon : Official Journal of the International Society on Toxinology·Yedidia Bentur, Alfred Cahana

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Citations

Mar 12, 2010·Toxicon : Official Journal of the International Society on Toxinology·Jean-Philippe ChippauxAchille Massougbodji
Mar 31, 2009·The Journal of Emergency Medicine·Yael Lurie, Yedidia Bentur
Nov 13, 2007·Acta Tropica·Aegachai Thiansookon, Ponlapat Rojnuckarin
Sep 24, 2013·Toxicon : Official Journal of the International Society on Toxinology·Guillermo LeónJosé María Gutiérrez
Jan 21, 2017·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Dikla Pivko-LevyMiguel Glatstein
Jun 27, 2020·Journal of Veterinary Emergency and Critical Care·Ran NivyYaron Bruchim
Dec 17, 2011·Toxins·Tatjana MomicPhilip Lazarovici
Feb 27, 2020·Journal of Occupational Medicine and Toxicology·Suha S SulaimanSa'ed H Zyoud
Dec 3, 2021·PLoS Neglected Tropical Diseases·Timothy P JenkinsAndreas H Laustsen

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