Evaluation of Apelin/APJ system expression in hepatocellular carcinoma as a function of clinical severity.

Clinical and Experimental Medicine
Manuela CabiatiSilvia Del Ry

Abstract

Apelin, a peptide of 77 amino acids, and its endogenous ligand, angiotensin-like-receptor 1 (APJ), play a key role in the development of tumors by enhancing angiogenesis, metastasis, cell proliferation, development of cancer stem cells and drug resistance and inhibiting apoptosis of cancer cells. However, little is known about Apelin/APJ system involvement in hepatocellular carcinoma (HCC). The aim of this study was to evaluate Apelin and APJ expression in liver specimens, obtained from subjects with HCV-positive HCC who underwent liver transplantation, according to liver disease severity (liver recipients, LR, n = 14, age 59.4 ± 1.8) and in donors (liver donors, LD, n = 14, age 62.1 ± 17.3). Apelin/APJ axis, apoptotic and inflammatory markers were evaluated by Real-Time PCR analysis. The Apelin/APJ system expression resulted significantly higher in LR in comparison with LD (p < 0.05), in particular in those with more severe liver disease. The apoptotic (Bcl-2, BAX, NOTCH-1, Casp-3) and inflammatory (IL-6, TNF-α) markers were increased as a function of disease severity (p < 0.05). Multiple significant positive correlations were found between Apelin/APJ axis and the other markers. Although further investigations are needed to be...Continue Reading

References

Jul 19, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·R H WiesnerW R Kim
Jan 4, 2003·Gastroenterology·Russell WiesnerUNKNOWN United Network for Organ Sharing Liver Disease Severity Score Committee
Mar 25, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Tatsuo HashimotoSatoshi Umemura
May 12, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R B FreemanA M Harper
Jun 15, 2007·Toxicologic Pathology·Susan Elmore
Sep 8, 2007·Journal of Molecular Histology·Zhiqin WangSuimin Qiu
Jul 31, 2008·World Journal of Gastroenterology : WJG·Asmaa-Ibrahim GomaaSimon-D Taylor-Robinson
Oct 17, 2008·Future Oncology·Catherine CavardChristine Perret
Apr 21, 2010·Annals of Surgical Oncology·Andrew X Zhu
Jun 29, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Judit BertaBalazs Dome
Mar 10, 2011·Nature Reviews. Clinical Oncology·Andrew X ZhuRakesh K Jain
Mar 19, 2011·Cell Death and Differentiation·P N Kelly, A Strasser
May 11, 2011·Anti-cancer Agents in Medicinal Chemistry·Hung HuynhIrene Wei Ling Lam
Oct 14, 2011·Future Oncology·Qian ZhouWinnie Yeo
Aug 27, 2013·Biochemical and Biophysical Research Communications·Qi-Feng LiuGui-Zhou Tao
Jan 29, 2014·Clinical and Experimental Medicine·Antonio LacquanitiMichele Buemi
Feb 19, 2014·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Jun MutoYoshihiko Maehara
Oct 24, 2015·The International Journal of Biochemistry & Cell Biology·Cheng WangLiling Wu
Sep 17, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Pierluigi ToniuttoPatrizia Burra
May 28, 2017·Life Sciences·Mojgan Noroozi KarimabadGholamhossein Hassanshahi
Oct 3, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael A MorseRichard S Finn
Feb 23, 2020·Clinical and Experimental Medicine·Susanne FederChrista Buechler
Feb 23, 2020·Advances in Medical Sciences·Javad MasoumiNajmeh Jamali
Jul 28, 2020·Clinical and Experimental Medicine·Chunyu Cao, Changjiang Wang

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Citations

Apr 30, 2021·Frontiers in Oncology·Longfei LiuXiao Guan
Jun 3, 2021·Cancers·Joanna OlszańskaDorota Nowak
Jul 27, 2021·World Journal of Clinical Cases·Gulsum Ozlem Elpek

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