PMID: 8969892Nov 1, 1996Paper

Evaluation of apoptotic parameters in normal and neoplastic human adrenal

Endocrine Research
G W WolkersdörferS R Bornstein

Abstract

The migration and proliferation of adrenocortical cells is accompanied by mechanisms of cellular knock-out. We compared the programmed cell death of normal and malignant adrenocortical tissues on the basis of apoptotic rates by the nonradioactive in situ end-labelling of DNA-fragments, immunohistochemistry against PCNA, CD95 and ultrastructural analysis. The highest labelling index (LI) was detectable in the outermost zones of the adrenal cortex of normal adrenals. Average LI in normal adrenal cortex was 20% whereas only 2% was detectable in adrenocortical neoplasms. MHC class II, which was previously shown to be involved in programmed cell death in lymphocyte populations (1), was detectable in normal and benign but not in malignant adrenocortical neoplastic cells. In conclusion, the analysis of apoptosis provides new aspects of normal adrenal zonation and allows the differentiation between normal and neoplastic adrenal cortex although the differentiation between malignant and benign neoplasms requires further markers.

References

Jan 1, 1980·International Review of Cytology·A H WyllieA R Currie
Feb 1, 1995·Critical Reviews in Oncology/hematology·S J Martin, D R Green
Jun 1, 1994·International Immunology·J P TrumanN A Mooney
Apr 1, 1996·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·S R BornsteinL M Fishman

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Citations

Aug 11, 1998·Biochemical Pharmacology·G W Wolkersdörfer, S R Bornstein
Aug 26, 1998·The Journal of Steroid Biochemistry and Molecular Biology·V AdleffE Gláz
Jun 1, 2002·Ageing Research Reviews·Peter J Hornsby
Oct 20, 1998·The American Journal of Pathology·Y SoiniV P Lehto
Aug 5, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Stefan R BornsteinGraeme Eisenhofer
Jan 15, 1999·Endocrine Research·G W WolkersdörferS R Bornstein
Oct 16, 2019·Proceedings of the National Academy of Sciences of the United States of America·Alexia BelavgeniAndreas Linkermann

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