PMID: 6981802Jan 1, 1982Paper

Evaluation of assays to detect immune complexes as an immunodiagnostic aid in patients with melanoma

Oncodevelopmental Biology and Medicine : the Journal of the International Society for Oncodevelopmental Biology and Medicine
P RuellP Hersey

Abstract

Sera from 211 melanoma patients were tested before and after surgery for the presence of immune complexes (i.c.) by the 125I-C1q radioimmunoassay (C1q RIA) and a nephelometric monoclonal rheumatoid factor assay (mRhF). The patients were grouped according to stage of disease and therapy. Before surgery stage III patients had a higher incidence of i.c. (26.9%) than stage II (17.5%) and stage I (6.1%) patients. The incidence of i.c. in the latter patients did not differ from that of normal controls. Stage I patients treated with BCG therapy had a higher incidence of i.c. before and after surgery to remove melanoma compared with untreated patients. The incidence of i.c. in stage I and II patients was higher in sera taken after surgical removal of tumour compared to that in sera taken before surgery. Sequential studies revealed that i.c. often appeared then disappeared prior to clinical detection of recurrences. These results suggested that antigen excess was a frequent cause for failure to detect i.c. A prospective evaluation of the usefulness of assays for i.c. to monitor disease activity in melanoma patients was conducted. In some individual patients detection of i.c. was a prelude to recurrence from melanoma but the high false n...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.