Evaluation of atrial septal defects with 4D flow MRI-multilevel and inter-reader reproducibility for quantification of shunt severity

Magma
Raluca G CheluAlbert Hsiao

Abstract

With the hypothesis that 4D flow can be used in evaluation of cardiac shunts, we seek to evaluate the multilevel and interreader reproducibility of measurements of the blood flow, shunt fraction and shunt volume in patients with atrial septum defect (ASD) in practice at multiple clinical sites. Four-dimensional flow MRI examinations were performed at four institutions across Europe and the US. Twenty-nine patients (mean age, 43 years; 11 male) were included in the study. Flow measurements were performed at three levels (valve, main artery and periphery) in both the pulmonary and systemic circulation by two independent readers and compared against stroke volumes from 4D flow anatomic data. Further, the shunt ratio (Qp/Qs) was calculated. Additionally, shunt volume was quantified at the atrial level by tracking the atrial septum. Measurements of the pulmonary blood flow at multiple levels correlate well whether measuring at the valve, main pulmonary artery or branch pulmonary arteries (r = 0.885-0.886). Measurements of the systemic blood flow show excellent correlation, whether measuring at the valve, ascending aorta or sum of flow from the superior vena cava (SVC) and descending aorta (r = 0.974-0.991). Intraclass agreement betw...Continue Reading

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Citations

May 10, 2020·Journal of Magnetic Resonance Imaging : JMRI·Javier Urmeneta UlloaJosé Ángel Cabrera
Jul 28, 2020·Radiology. Cardiothoracic Imaging·Francisco J ContijochAlbert Hsiao
Apr 10, 2019·The International Journal of Cardiovascular Imaging·Kelly StamAlexander Hirsch
May 5, 2020·Journal of Magnetic Resonance Imaging : JMRI·Jos J M WestenbergHildo J Lamb
May 11, 2021·Radiology. Cardiothoracic Imaging·Michael J HorowitzAlbert Hsiao
Jun 3, 2021·AJR. American Journal of Roentgenology·Kathleen JacobsAlbert Hsiao

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Methods Mentioned

BETA
imaging techniques
imaging technique

Software Mentioned

SPSS
GraphPad Prism

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