Evaluation of basal plasma α-melanocyte-stimulating hormone and adrenocorticotrophic hormone concentrations for the diagnosis of pituitary pars intermedia dysfunction from a population of aged horses

Equine Veterinary Journal
T W Mc GowanC M Mc Gowan

Abstract

The sensitivity and specificity of basal plasma α-melanocyte-stimulating hormone (α-MSH) and adrenocorticotrophic hormone (ACTH) for the diagnosis of pituitary pars intermedia dysfunction (PPID) has not been evaluated in a population-based study. To evaluate basal plasma α-MSH and ACTH concentrations for the diagnosis of PPID in a population of horses aged ≥ 15 years. Owner-reported data were obtained using a postal questionnaire distributed to an equestrian group. A subgroup of surveyed owners was visited and veterinary examination performed on horses aged ≥ 15 years. Blood samples were analysed for plasma α-MSH and ACTH concentrations. Seasonally adjusted cut-off values for α-MSH and ACTH concentrations for the diagnosis of PPID were obtained using Youden index values against a clinical gold standard diagnosis (hirsutism plus 3 or more clinical signs of PPID). α-melanocyte-stimulating hormone and ACTH were highly correlated with each other and with clinical and historical indicators of PPID. The increase in both α-MSH and ACTH with increasing numbers of clinical signs in affected horses supports a spectrum of disease. Both variables were affected by season, with derived cut-off values being higher in autumn compared with othe...Continue Reading

References

Jan 1, 1995·Domestic Animal Endocrinology·J H van der KolkH J Breukink
Jan 8, 2005·The Veterinary Clinics of North America. Equine Practice·Harold C Schott
Sep 16, 2005·Biometrical Journal. Biometrische Zeitschrift·Ronen FlussBenjamin Reiser
Dec 29, 2005·American Journal of Veterinary Research·Dianne McFarlaneAlastair E Cribb
Apr 26, 2008·Biometrical Journal. Biometrische Zeitschrift·Marcus D RuoppEnrique F Schisterman
Oct 21, 2010·Australian Veterinary Journal·T W McGowanC M McGowan
Oct 12, 2011·Journal of Veterinary Internal Medicine·A P PeaseJ S Patterson

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Citations

Jun 23, 2016·The Veterinary Clinics of North America. Equine Practice·Derek C Knottenbelt
Nov 3, 2016·American Journal of Veterinary Research·Kelsey A HartKathern E Myrna
Sep 19, 2014·Veterinary Pathology·N P KarikoskiJ C Patterson-Kane
Jun 15, 2018·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Justine C R ShottonBarbara Bacci
Jan 31, 2019·Journal of Veterinary Internal Medicine·Melody A de LaatDania B Reiche
Apr 12, 2019·Journal of Veterinary Internal Medicine·Melody A de LaatJames M McGree
Dec 18, 2013·Equine Veterinary Journal·J E Sojka-Kritchevsky, P J Johnson
Apr 3, 2016·Equine Veterinary Journal·M A de Laat, M N Sillence
Dec 26, 2018·Frontiers in Microbiology·Philippa K MorrisonCaroline McG Argo
May 30, 2020·Equine Veterinary Journal·Andy E DurhamGeorge L Malone
Apr 10, 2021·Equine Veterinary Journal·Marcus Bennett, Catherine M McGowan

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