Evaluation of basal sex hormone levels for activation of the hypothalamic-pituitary-gonadal axis.

Journal of Pediatric Endocrinology & Metabolism : JPEM
Yu DingShijian Liu

Abstract

This study aimed to identify the predictive value of basal sex hormone levels for activation of the hypothalamic-pituitary-gonadal (HPG) axis in girls. Gonadotropin-releasing hormone (GnRH) stimulation tests were performed and evaluated in a total of 1750 girls with development of secondary sex characteristics. Correlation analyses were conducted between basal sex hormones and peak luteinizing hormone (LH) levels ≥5 IU/L during the GnRH stimulation test. Receiver operating characteristic (ROC) curves for basal levels of LH, follicle-stimulating hormone (FSH), LH/FSH, and estradiol (E2) before the GnRH stimulation test were plotted. The area under the curve (AUC) and 95% confidence intervals (CIs) were measured for each curve. The maximum AUC value was observed for basal LH levels (0.77, 95% CI: 0.74-0.79), followed by basal FSH levels (0.73, 95% CI: 0.70-0.75), the basal LH/FSH ratio (0.68, 95% CI: 0.65-0.71), and basal E2 levels (0.61, 95% CI: 0.59-0.64). The appropriate cutoff value of basal LH levels associated with a positive response of the GnRH stimulation test was 0.35 IU/L, with a sensitivity of 63.96% and specificity of 76.3% from the ROC curves when Youden's index showed the maximum value. When 100% of patients had pe...Continue Reading

References

Jul 1, 1995·The Journal of Pediatrics·E K NeelyM Stene
Oct 16, 1999·The Journal of Clinical Endocrinology and Metabolism·V N BritoB B Mendonca
Jun 6, 2000·Indian Journal of Pediatrics·A Diaz, M Danon
Sep 2, 2000·Journal of Pediatric Endocrinology & Metabolism : JPEM·L IughettiS Bernasconi
Mar 18, 2008·Arquivos brasileiros de endocrinologia e metabologia·Maria F BorgesBeatriz P Ferreira
May 30, 2008·The New England Journal of Medicine·Jean-Claude Carel, Juliane Léger
Feb 25, 2011·The Journal of Clinical Endocrinology and Metabolism·Signe Sloth MogensenAnders Juul
Oct 22, 2011·The Korean journal of laboratory medicine·Han Kyul KimChan Jong Kim
Nov 16, 2011·European Journal of Endocrinology·Yehonatan PasternakEli Hershkovitz
Aug 16, 2012·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·H S LeeJ S Hwang
Jun 2, 2015·Journal of Pediatric Endocrinology & Metabolism : JPEM·Meliksah KeskinZehra Aycan
Dec 4, 2015·International Journal of Environmental Research and Public Health·Yi WenQin Liu

❮ Previous
Next ❯

Citations

May 23, 2020·Journal of Pediatric Endocrinology & Metabolism : JPEM·Valeria CalcaterraDaniela Larizza
Oct 18, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Li-Hua CaoXiu-Min Li

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray

Software Mentioned

Stata

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved