Evaluation of behavioral parameters, hematological markers, liver and kidney functions in rodents exposed to Deepwater Horizon crude oil and Corexit

Life Sciences
Sindhu RameshMuralikrishnan Dhanasekaran

Abstract

The 2010 Deepwater Horizon (DWH) oil spill is the largest marine oil spill in US history. In the aftermath of the spill, the response efforts used a chemical dispersant, Corexit, to disperse the oil spill. The health impacts of crude oil and Corexit mixture to humans, mammals, fishes, and birds are mostly unknown. The purpose of this study is to investigate the in vivo effects of DWH oil, Corexit, and oil-Corexit mixture on the general behavior, hematological markers, and liver and kidney functions of rodents. C57 Bl6 mice were treated with DWH oil (80 mg/kg) and/or Corexit (95 mg/kg), and several hematological markers, lipid profile, liver and kidney functions were monitored. The results show that both DWH oil and Corexit altered the white blood cells and platelet counts. Moreover, they also impacted the lipid profile and induced toxic effects on the liver and kidney functions. The impacts were more pronounced when the mice were treated with a mixture of DWH-oil and Corexit. This study provides preliminary data to elucidate the potential toxicological effects of DWH oil, Corexit, and their mixtures on mammalian health. Residues from the DWH spill continue to remain trapped along various Gulf Coast beaches and therefore further...Continue Reading

Citations

Dec 14, 2019·Environmental Health Perspectives·Gary L GinsbergJohn R Bucher
Sep 4, 2020·Environmental Science and Pollution Research International·Krissia Aparecida de AlmeidaFlavio Manoel Rodrigues da Siva Júnior
Jul 26, 2018·Marine Pollution Bulletin·Gerald F JohnT Prabhakar Clement
Mar 7, 2021·International Journal of Environmental Research and Public Health·Khalid SayedNaresh Kumar Sharma
Oct 9, 2021·Cardiovascular Toxicology·Satyanarayana R PondugulaMuralikrishnan Dhanasekaran

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