Evaluation of Benefit and Tolerability of IQP-CL-101 (Xanthofen) in the Symptomatic Improvement of Irritable Bowel Syndrome: A Double-Blinded, Randomised, Placebo-Controlled Clinical Trial

Phytotherapy Research : PTR
Felix AltRalf Uebelhack

Abstract

Irritable bowel syndrome (IBS) is a functional bowel disorder of unknown aetiology. There is currently no known cure, and pharmacological interventions are usually targeting symptomatic relief, where natural and herbal remedies also play a role. This study aimed to evaluate the benefit and tolerability of IQP-CL-101 in symptomatic IBS relief. A double-blinded, randomised, placebo-controlled trial was conducted over 8 weeks. A total of 99 subjects fulfilling ROME-III criteria for IBS were randomised into two groups, given either two IQP-CL-101 softgels or matching placebo twice daily before main meals. The primary endpoint was the difference in change of IBS Symptom Severity Score (IBS-SSS) after an 8-week intake of IQP-CL-101 compared to placebo. After 8 weeks, subjects on IQP-CL-101 showed a significant reduction in IBS-SSS (113.0 ± 64.9-point reduction) compared to subjects on placebo (38.7 ± 64.5-point reduction) (p < 0.001). A significant improvement could be seen as early as 4 weeks. No serious adverse events were reported throughout. IQP-CL-101 can be considered beneficial in the improvement of IBS symptom severity, regardless of IBS type, and therefore able to improve quality of life in patients suffering from abdominal ...Continue Reading

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Citations

Sep 6, 2017·Current Opinion in Clinical Nutrition and Metabolic Care·Eirini DimidiKevin Whelan
Feb 23, 2020·The American Journal of Gastroenterology·Jill K DeutschDavid J Hass
Nov 2, 2019·Journal of Gastroenterology and Hepatology·Niandi TanYinglian Xiao
Jul 6, 2020·Chinese Journal of Integrative Medicine·Hamide Khorram PazhouhMohammadreza Noras
Mar 7, 2018·Phytotherapy Research : PTR
Sep 27, 2018·Journal of Clinical Medicine·Qin Xiang NgWee-Song Yeo
Dec 2, 2017·Phytotherapy Research : PTR·Cristiano Colalto
Jul 6, 2019·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Nazanin Momeni RoudsariAmir Hossein Abdolghaffari
Sep 23, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Wade BillingsAndrea Shin

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