Evaluation of bilosomes as nanocarriers for transdermal delivery of tizanidine hydrochloride: in vitro and ex vivo optimization

Journal of Liposome Research
Rawia M KhalilHadeer A El-Hashemy

Abstract

Bilosomes were developed in order to investigate their efficacy as nanocarriers for transdermal delivery of Tizanidine HCl (TZN), a skeletal muscle relaxant with low oral bioavailability. Full factorial experimental design consisting of 27 combinations was generated to study the effects of surfactant type, surfactant-to-cholesterol ratio and the amount of bile salt on the entrapment efficiency (EE), the vesicle size (VS) and in vitro dissolution of the TZN-loaded bilosomes. The permeation through the stratum cornea was optimized with the vertical diffusion assembly using excised rat skin. The permeation parameters of the selected bilosomes were compared to the unformulated drug and it was shown that TZN-B24 exhibited the highest enhancement ratio (ER = 8.8).The optimal formula (TZN-B24) consisting of span 60 in a ratio with cholesterol of 1:1 and 20 mg of bile salt was obtained by employing the desirability function of Design-Expert® software. The mathematical model used for the optimization was validated by comparing the predicted values of the EE (82.3%) and the VS (165.8 nm) with the experimental values of EE = 84.42% and of VS = 161.95 nm. TZN-B24 displayed high zeta potential which contributed to its good stability. It was...Continue Reading

References

Nov 1, 1993·Journal of Pharmaceutical Sciences·G P KushlaR S Berger
Sep 3, 2002·International Journal of Pharmaceutics·Yongmei HaoKe'an Li
Jan 17, 2004·International Journal of Pharmaceutics·A ManosroiJ Manosroi
Feb 16, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Chiara SinicoAnna Maria Fadda
Sep 26, 2006·International Journal of Pharmaceutics·Abbas PardakhtyAbdolhossein Rouholamini
Mar 15, 2008·International Journal of Pharmaceutics·A Abd-ElbaryM I Tadros
Jun 20, 2008·AAPS PharmSciTech·Ghada Abdelbary, Nashwa El-Gendy
Apr 1, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ramesh C NagarwalJ K Pandit
Sep 26, 2009·Journal of Pharmaceutical Sciences·Zerrin Sezgin Bayindir, Nilufer Yuksel
Dec 23, 2009·Pharmaceutical Development and Technology·Ghada Abdelbary
Jul 6, 2010·International Journal of Pharmaceutics·Ghada M El ZaafaranyNahed D Mortada
Feb 10, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Rita MuzzalupoNevio Picci
Jun 21, 2011·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Komuravelly SomeshwarK K Kalyan Kumar
Jan 29, 2013·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Anchal Sankhyan, Pravin K Pawar
Apr 24, 2013·Journal of Liposome Research·Mona BashaGhada E A Awad
Jul 10, 2013·Journal of Liposome Research·A N ElmeshadM R Mozafari
Aug 13, 2013·BioMed Research International·Saeed Ghanbarzadeh, Sanam Arami
Apr 1, 2014·International Journal of Pharmaceutics·Galal M El-MahroukMaie S Taha
Apr 1, 2005·Drug Discovery Today. Technologies·P Loan Honeywell-Nguyen, Joke A Bouwstra
Jul 10, 2014·Drug Delivery·Harneet MarwahGoutam Rath
Aug 16, 2014·International Journal of Pharmaceutical Investigation·Mohd YusufKamla Pathak
Mar 23, 2015·International Journal of Pharmaceutics·Abdulaziz M Al-MahallawiMona H Aburahma
Mar 17, 2016·Drug Development and Industrial Pharmacy·M L González-RodríguezA M Rabasco
Sep 3, 2016·Pharmaceutics·Rajan RajabalayaSheba R David

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Citations

May 16, 2020·Nanomedicine·Sarwar BegMahfoozur Rahman
Jul 1, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Leonna DsouzaShaila A Lewis

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