Evaluation of Biocompatibility and Release of Reactive Oxygen Species of Aluminum Oxide-Coated Materials

ACS Omega
Gemma MestresMarjam Ott

Abstract

Surface properties of biomaterials can strongly influence biomaterial-host interactions. For this reason, coating processes open a wide range of possibilities to modulate the fate of a biomaterial in the body. This study evaluates the effect of a coating material intended for drug delivery capsules on biocompatibility and the release of reactive oxygen species (ROS), that is, respiratory burst in macrophages that indicates acute inflammation. In parallel with a new approach to develop drug-delivery capsules by directly coating solid-state drug particles, in this study, glass slides and silicon nanoparticles (NPs) were coated with aluminum oxide (Al2O3) using atomic layer deposition. Different sizes of NPs (20 and 310 nm) were suspended at different concentrations (10, 100, and 1000 μg/mL) and were evaluated. The homogeneous coating of slides was proved using X-ray photoelectron spectroscopy, and the coating on NP was observed using transmission electron microscopy. Human dermal fibroblasts and human osteoblasts were able to proliferate on the coated slides and in the presence of a suspension of coated NPs (20 and 310 nm) at a low concentration (10 μg/mL). The macrophages released ROS only when in contact with NPs at a concentra...Continue Reading

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Citations

Sep 7, 2018·Journal of Cellular Physiology·Maryam Rahmati, Masoud Mozafari
Sep 29, 2020·International Journal of Nanomedicine·Li ZhangFrank A Schildberg
Jun 5, 2019·Journal of Biomedical Materials Research. Part a·Ting LiJianhua Wang

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Methods Mentioned

BETA
X-ray
transmission electron microscopy

Software Mentioned

SPSS Statistics

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