PMID: 22563667May 9, 2012Paper

Evaluation of biological protein-based collagen scaffolds in cartilage and musculoskeletal tissue engineering--a systematic review of the literature

Current Stem Cell Research & Therapy
Pouya MafiWasim S Khan

Abstract

The term tissue engineering is the technology that combines cells, engineering and biological/synthetic material in order to repair, replace or regenerate biological tissues such as bone, muscle, tendons and cartilage. The major human applications of tissue engineering are: skin, bone, cartilage, corneas, blood vessels, left mainstem bronchus and urinary structures. In this systematic review several criteria were identified as the most desirable characteristics of an ideal scaffold. These state that an ideal scaffolds needs to be biodegradable, possess mechanical strength, be highly porous, biocompatible, non-cytotoxic, non antigentic, stuitable for cell attachment, proliferation and differentiation, flexible and elastic, three dimensional, osteoconductive and support the transport of nutrients and metabolic waste. Subsequently, studies reporting on the various advantages and disadvantages of using collagen based scaffolds in musculoskeletal and cartilage tissue engineering were identified. The purpose of this review is to 1) provide a list of ideal characteristics of a scaffold as identified in the literature 2) identify different types of biological protein-based collagen scaffolds used in musculoskeletal and cartilage tissue...Continue Reading

Citations

May 9, 2013·TheScientificWorldJournal·Thomas E KrugerJinxi Wang
Apr 9, 2014·Journal of Translational Medicine·Jie-Lin ChenDaping Wang
Jun 26, 2014·International Orthopaedics·Nadomir GusićSaša Janković
Nov 30, 2012·Journal of Tissue Engineering and Regenerative Medicine·Silke SchwarzNicole Rotter
Jan 18, 2014·Journal of Structural Biology·Zhuoxin YuBarbara Brodsky
Jan 24, 2019·Cell and Tissue Banking·Riccardo D'AmbrosiNicola Ursino
Jul 3, 2017·Tissue Engineering and Regenerative Medicine·Soyoung HongChangmo Hwang
Jan 16, 2020·Materials·Haowen KwanWasim S Khan
Sep 2, 2016·Biomacromolecules·Nelda Vázquez-Portalatı NJulie C Liu
Nov 18, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Hui YuanMarkus Valtiner

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