Evaluation of Biomarkers in Critical Care and Perioperative Medicine: A Clinician’s Overview of Traditional Statistical Methods and Machine Learning Algorithms

Anesthesiology
Sabri SoussiYannick Le Manach

Abstract

Interest in developing and using novel biomarkers in critical care and perioperative medicine is increasing. Biomarkers studies are often presented with flaws in the statistical analysis that preclude them from providing a scientifically valid and clinically relevant message for clinicians. To improve scientific rigor, the proper application and reporting of traditional and emerging statistical methods (e.g., machine learning) of biomarker studies is required. This Readers' Toolbox article aims to be a starting point to nonexpert readers and investigators to understand traditional and emerging research methods to assess biomarkers in critical care and perioperative medicine.

References

Dec 1, 1996·Journal of Clinical Epidemiology·P PeduzziA R Feinstein
Jun 19, 2003·Journal of Clinical Epidemiology·Ewout W SteyerbergKarel G M Moons
Nov 28, 2008·BMC Medical Informatics and Decision Making·Andrew J VickersMithat Gonen
Feb 27, 2009·Journal of the American Society of Nephrology : JASN·Sushrut S Waikar, Joseph V Bonventre
Mar 18, 2010·Anesthesiology·Patrick RayTim T Houle
May 11, 2011·American Journal of Epidemiology·Margaret S Pepe
Aug 28, 2013·International Urology and Nephrology·Ping L ZhangJason M Hafron
May 3, 2014·Journal of the American Society of Nephrology : JASN·Chirag R Parikh, Heather Thiessen-Philbrook
May 24, 2014·The Lancet. Respiratory Medicine·Carolyn S CalfeeUNKNOWN NHLBI ARDS Network
Dec 24, 2014·BMC Medical Research Methodology·Tjeerd van der PloegEwout W Steyerberg
Apr 19, 2015·Critical Care : the Official Journal of the Critical Care Forum·Alexander KutzPhilipp Schuetz
Oct 30, 2015·Clinical Chemistry·Patrick M BossuytUNKNOWN STARD Group
Nov 12, 2015·Statistics in Medicine·Ian SchillerNandini Dendukuri
Jan 27, 2016·BMJ : British Medical Journal·Andrew J VickersEwout W Steyerberg
Mar 12, 2016·Journal of Clinical Epidemiology·Emmanuel O OgundimuGary S Collins
Jun 9, 2016·Annals of Translational Medicine·Zhongheng Zhang
Nov 25, 2016·BMC Medical Research Methodology·Maarten van SmedenJohannes B Reitsma
Nov 29, 2016·Statistics in Medicine·Yvonne VergouweEwout W Steyerberg
Jan 20, 2018·Critical Care : the Official Journal of the Critical Care Forum·Etienne GayatAlexandre Mebazaa
Mar 14, 2018·JAMA : the Journal of the American Medical Association·Andrew L Beam, Isaac S Kohane
May 13, 2018·Chest·L Nelson Sanchez-PintoMatthew M Churpek
May 14, 2018·Critical Care : the Official Journal of the Critical Care Forum·Daniel O Thomas-RüddelUNKNOWN MEDUSA study group
May 17, 2018·Trauma Surgery & Acute Care Open·Lorraine B WareCarolyn S Calfee
Aug 7, 2018·The Lancet. Respiratory Medicine·Carolyn S CalfeeUNKNOWN Irish Critical Care Trials Group
Jan 9, 2019·Frontiers in Cardiovascular Medicine·Hendrik T Tevaearai StahelThierry P Carrel
Feb 15, 2019·Journal of Clinical Epidemiology·Evangelia ChristodoulouBen Van Calster
Apr 10, 2019·Critical Care : the Official Journal of the Critical Care Forum·Zhongheng ZhangYucai Hong
Apr 17, 2019·Clinical Chemistry·Jasper BoeddinghausUNKNOWN APACE investigators

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