Evaluation of Biomarkers of Exposure in Smokers Switching to a Carbon-Heated Tobacco Product: A Controlled, Randomized, Open-Label 5-Day Exposure Study

Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
Frank LüdickeJohn Magnette

Abstract

Tobacco harm reduction aims to provide reduced risk alternatives to adult smokers who would otherwise continue smoking combustible cigarettes (CCs). This randomized, open-label, three-arm, parallel-group, single-center, short-term confinement study aimed to investigate the effects of exposure to selected harmful and potentially harmful constituents (HPHCs) of cigarette smoke in adult smokers who switched to a carbon-heated tobacco product (CHTP) compared with adult smokers who continued to smoke CCs and those who abstained from smoking for 5 days. Biomarkers of exposure to HPHCs, including nicotine and urinary excretion of mutagenic material, were measured in 24-hour urine and blood samples in 112 male and female Caucasian smokers switching from CCs to the CHTP ad libitum use. Puffing topography was assessed during product use. Switching to the CHTP or smoking abstinence (SA) resulted in marked decreases from baseline to Day 5 in all biomarkers of exposure measured, including carboxyhemoglobin (43% and 55% decrease in the CHTP and SA groups, respectively). The urinary excretion of mutagenic material was also markedly decreased on Day 5 compared with baseline (89% and 87% decrease in the CHTP and SA groups, respectively). No cha...Continue Reading

References

Sep 1, 1991·British Journal of Addiction·T F HeathertonK O Fagerström
Jan 3, 1997·Mutation Research·K MureK Morimoto
Mar 24, 1999·Journal of the National Cancer Institute·D Holzman
Nov 10, 2000·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·A R Buchhalter, T Eissenberg
Jun 9, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Neal L BenowitzDelia Dempsey
Jan 27, 2006·Tobacco Control·R S CaraballoN Gupta
Jun 16, 2006·Inhalation Toxicology·Gerhard SchererKirsten Riedel
Jun 29, 2006·Journal of Analytical Toxicology·Kirsten RiedelAnthony R Tricker
Apr 25, 2007·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Linda L Pederson, David E Nelson
Nov 17, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Neal L BenowitzPeyton Jacob
Nov 8, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Vaughan W ReesGregory N Connolly
Nov 22, 2008·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Mohamadi SarkarHans Roethig
Mar 26, 2009·Chemical Research in Toxicology·Steven G CarmellaStephen S Hecht
Dec 5, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Catalin MarianPeter G Shields
Sep 7, 2012·Regulatory Toxicology and Pharmacology : RTP·Anthony R TrickerRuth Dempsey
Sep 20, 2012·Critical Reviews in Toxicology·M TalikkaM C Peitsch
Mar 19, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ulrike KogelManuel C Peitsch
Jan 13, 2015·Regulatory Toxicology and Pharmacology : RTP·Eugenia H TheophilusMichael F Borgerding
Apr 4, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Marco van der ToornHector De Leon
Apr 7, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Blaine PhillipsManuel C Peitsch
Oct 1, 2015·The New England Journal of Medicine·Michael Fiore, Timothy Baker

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Citations

Jul 28, 2016·Regulatory Toxicology and Pharmacology : RTP·Maurice R SmithManuel C Peitsch
Oct 22, 2016·Drug and Alcohol Dependence·Alexa A LopezAlison B Breland
Jan 4, 2018·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Michael John PeckRolf Weitkunat
Sep 6, 2018·Tobacco Control·Erikas SimonaviciusLeonie S Brose
Oct 24, 2019·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Aaron DrovandiTherese Kairuz
Nov 16, 2018·Revue des maladies respiratoires·B Dautzenberg, M-D Dautzenberg
Jul 3, 2021·International Journal of Environmental Research and Public Health·Małgorzata ZnykDorota Kaleta
Sep 18, 2021·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Jiyeon YangYoungwook Lim

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