Evaluation of bone turnover in postmenopause, vertebral fracture, and hip fracture using biochemical markers for bone formation and resorption

Journal of Endocrinological Investigation
M TakahashiT Inoue

Abstract

The purpose of this study is to evaluate bone turnover in postmenopausal status and established osteoporosis with vertebral fracture and hip fracture by assessing bone biochemical markers. Subjects were 50 healthy premenopausal subjects, 44 healthy postmenopausal subjects, 30 osteoporotic patients with vertebral fracture, and 31 osteoporotic patients with hip fracture. Alkaline phosphatase, osteocalcin, PICP, ICTP, NTx, free deoxypyridinoline, total pyridinoline and deoxypyridinoline were measured. In postmenopause, both Z-scores of bone formation markers and resorption markers were around 1-2. In osteoporosis, although Z-scores of bone formation markers were 0.4-2.8, resorption markers were 2.3-9.5. Moreover, Z-scores of resorption markers were higher in hip fracture than in vertebral fracture. These results indicate that bone formation and resorption increased and balanced in postmenopausal status. However, bone resorption increased more than bone formation and did not balance at all in osteoporosis. This imbalance is greater in hip fractures than in vertebral fractures.

References

Nov 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D A HansonD R Eyre
Oct 1, 1987·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A M ParfittS M Krane
Jan 1, 1987·Methods in Enzymology·D Eyre
Apr 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P GarneroP D Delmas
May 1, 1995·Calcified Tissue International·C K CheungR Swaminathan
Sep 1, 1994·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T ChevalleyJ P Bonjour
Oct 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S P RobinsM J Seibel
Sep 1, 1993·Calcified Tissue International·K AkessonK J Obrant
Sep 1, 1993·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R EastellR G Russell
Feb 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E F EriksenJ Risteli

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Citations

May 23, 2009·Transplantation Proceedings·M C GiovialeA I Lo Monte
Aug 3, 1999·British Journal of Obstetrics and Gynaecology·M TakahashiT Inoue
Jun 21, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Carolyn J CrandallDouglas C Bauer
Mar 11, 2010·Menopause : the Journal of the North American Menopause Society·Jong Ha HwangKyu Wan Lee
Mar 22, 2019·The Journal of Clinical Endocrinology and Metabolism·Emily A SouthmaydMary Jane De Souza
Jun 24, 2010·The Journal of Biological Chemistry·Akiyoshi HoshinoKenji Yamamoto
Dec 26, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·K KawanaK Kushida
Oct 15, 2021·The Journal of Bone and Joint Surgery. American Volume·Tamara D RozentalMary L Bouxsein

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