Evaluation of breast cancer risk in a multigenic model including low penetrance genes involved in xenobiotic and estrogen metabolisms

Nutrition and Cancer
Laetitia DelortDominique J Bernard-Gallon

Abstract

Breast cancer has become the most frequent cancer among women in Westernized countries. The majority of breast cancers are due to low penetrance genes, which can act with environmental factors, particularly nutrition. Polymorphisms in gene coding for xenobiotic and estrogen metabolic pathways could increase individual cancer susceptibility and lead to the indication of individuals at higher cancer risk. A population-based, case-control study consisting of 911 breast cancer cases and 1,000 healthy control cases was performed. The association between 11 single nucleotide polymorphisms (SNP) in 7 genes and breast cancer risk was investigated in a multigenic model. The CYP1B1-432 Leu-Val and Val-Val genotypes significantly increased risk [odds ratio (OR) = 1.23, 95% confidence interval (CI) = 1.08-1.39; OR = 1.51, 95% CI = 1.17-1.94, respectively] similarly as observed with CYP1B1-453 (Asn-Ser genotype: OR = 1.17, 95% CI = 1.00-1.37; Ser-Ser genotype: OR = 1.38, 95% CI = 1.00-1.89). We showed that catechol-O-methyltransferase (COMT) could modulate the risk conferred by CYP1B1, ESR, GSTP1, and NAT2 acetylation phenotype. Additionally, a higher risk conferred by the variant for COMT was noted only for individuals presenting a high wa...Continue Reading

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Citations

Apr 19, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Denise Maria ChristofoliniCaio Parente Barbosa
Jan 23, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tengfei Wang, Hany E Marei
Mar 10, 2012·Cancer Epidemiology·Rémy BosvielDominique J Bernard-Gallon
May 9, 2014·Journal of Ovarian Research·Emerson Barchi CordtsDenise Maria Christofolini
Dec 6, 2014·Molecular Genetics and Genomics : MGG·Jie-Ying LiuWei Wang
Jun 20, 2017·Molecular Medicine Reports·Chunjie WenHonghao Zhou
Aug 2, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Fang-Shuo TianBao-Sen Zhou
Nov 1, 2010·Experimental and Therapeutic Medicine·Weiping YeYoung C Lin

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Methods Mentioned

BETA
hormone replacement therapy
acetylation
ESR
genotyping

Software Mentioned

SEM

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