Abstract
Breast cancer has become the most frequent cancer among women in Westernized countries. The majority of breast cancers are due to low penetrance genes, which can act with environmental factors, particularly nutrition. Polymorphisms in gene coding for xenobiotic and estrogen metabolic pathways could increase individual cancer susceptibility and lead to the indication of individuals at higher cancer risk. A population-based, case-control study consisting of 911 breast cancer cases and 1,000 healthy control cases was performed. The association between 11 single nucleotide polymorphisms (SNP) in 7 genes and breast cancer risk was investigated in a multigenic model. The CYP1B1-432 Leu-Val and Val-Val genotypes significantly increased risk [odds ratio (OR) = 1.23, 95% confidence interval (CI) = 1.08-1.39; OR = 1.51, 95% CI = 1.17-1.94, respectively] similarly as observed with CYP1B1-453 (Asn-Ser genotype: OR = 1.17, 95% CI = 1.00-1.37; Ser-Ser genotype: OR = 1.38, 95% CI = 1.00-1.89). We showed that catechol-O-methyltransferase (COMT) could modulate the risk conferred by CYP1B1, ESR, GSTP1, and NAT2 acetylation phenotype. Additionally, a higher risk conferred by the variant for COMT was noted only for individuals presenting a high wa...Continue Reading
References
Dec 1, 1994·Carcinogenesis·F CroftsS J Garte
Aug 1, 1994·Cancer·R Ballard-Barbash
Sep 27, 1996·International Journal of Cancer. Journal International Du Cancer·S MännistöM Uusitupa
Apr 16, 1998·Journal of the National Cancer Institute·K J HelzlsouerD Bell
Mar 4, 1999·The Journal of Nutrition·R Sinha, N Caporaso
Mar 20, 1999·Genetic Analysis : Biomolecular Engineering·K J Livak
Dec 22, 1999·American Journal of Epidemiology·Z HuangS E Hankinson
Mar 30, 2000·Pharmacogenetics·J WatanabeK Kawajiri
Apr 6, 2001·International Journal of Cancer. Journal International Du Cancer·M KrajinovicD Sinnett
Apr 16, 2002·Journal of Medical Genetics·M M de JongE G E de Vries
Aug 15, 2002·Cancer Letters·Lídia da Fonte de AmorimLuis Pinto
Sep 28, 2002·Mutation Research·David W Hein
Nov 5, 2002·Archives of Toxicology·Neslihan Aygün KocabaşAli Esat Karakaya
Mar 6, 2003·British Journal of Cancer·K-M LeeD Kang
Jul 8, 2003·Carcinogenesis·Tove Rylander-RudqvistIngemar Persson
Jul 31, 2003·Mutation Research·Katja Mitrunen, Ari Hirvonen
Nov 26, 2003·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yasuo Miyoshi, Shinzaburo Noguchi
Apr 10, 2004·Cancer Letters·Bharat ThyagarajanMyron Gross
Jun 17, 2004·Journal of the National Cancer Institute·Alison M DunningBruce A J Ponder
Aug 24, 2004·Oncogene·Donald M Parkin
Sep 30, 2004·International Journal of Cancer. Journal International Du Cancer·Ting-Chih ChengChen-Yang Shen
Dec 8, 2004·American Journal of Epidemiology·Yawei ZhangTongzhang Zheng
Mar 24, 2005·Journal of Cellular and Molecular Medicine·R G Dumitrescu, I Cotarla
Apr 28, 2005·Cancer·Sonia M BoyapatiWei Zheng
Citations
Oct 9, 2012·Diagnostic Pathology·Xue QinJinmin Zhao
Apr 19, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Denise Maria ChristofoliniCaio Parente Barbosa
Jan 23, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tengfei Wang, Hany E Marei
Mar 10, 2012·Cancer Epidemiology·Rémy BosvielDominique J Bernard-Gallon
Dec 2, 2014·Toxicology·Cuiping LiYang Zhou
May 9, 2014·Journal of Ovarian Research·Emerson Barchi CordtsDenise Maria Christofolini
Jan 24, 2012·Vaccine·Richard B KennedyGregory A Poland
Dec 6, 2014·Molecular Genetics and Genomics : MGG·Jie-Ying LiuWei Wang
Jan 3, 2015·Cancer Causes & Control : CCC·Heather L BlackburnRachel E Ellsworth
Nov 9, 2016·Drug Metabolism Reviews·Katrin Sak
Mar 22, 2019·Medicine·Xiaoxiao ZhuXia Li
May 31, 2012·British Journal of Cancer·A DubrovskaP G Schultz
Jun 20, 2017·Molecular Medicine Reports·Chunjie WenHonghao Zhou
Feb 3, 2012·Molecular Biology Reports·Xiao-Feng HeWei Wang
Aug 2, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Fang-Shuo TianBao-Sen Zhou
Nov 1, 2010·Experimental and Therapeutic Medicine·Weiping YeYoung C Lin