PMID: 2117060Jan 1, 1990Paper

Evaluation of C. reactive protein values in neonatal sepsis

Journal of Perinatal Medicine
D B ShortlandG Harrison

Abstract

C. reactive protein (CRP) estimations were performed prospectively on 30 consecutive admissions of very low birth weight infants to a Regional neonatal intensive care unit. The samples were analysed by a recently described, rapid intralipid agglutination assay and by a reference turbidimetric technique. Two hundred and ninety samples were assayed by both techniques. The intralipid agglutination was positive on two occasions when the reference method found normal levels. No false negative reactions occurred. Bacterial micro-organisms were isolated on 32 occasions but 19 of the organisms were considered to represent bacterial colonisation or contamination. The CRP remained negative in 17 cases. There were 13 episodes of clinical deterioration associated with positive bacterial cultures. In each of the six infants with severe systemic infections (septicaemia (4), meningitis (1), and osteomyelitis (1)), the levels were raised. In five of these infants the CRP was elevated before, or at the time of, the clinical deterioration. The CRP remained normal during seven (54%) of the culture positive events. We believe that the CRP estimations provide additional information in the evaluation of the infant with suspected sepsis. Serial measu...Continue Reading

References

Nov 1, 1979·Acta paediatrica Scandinavica·K G Sabel, C Wadsworth
Feb 1, 1988·Archives of Disease in Childhood·J Stuart, J T Whicher
Mar 1, 1987·European Journal of Pediatrics·N J Mathers, F Pohlandt
May 30, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·B ShineC B Wood

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Citations

Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Liliana SimonJacques Lacroix
Dec 29, 2000·Journal of Perinatal Medicine·U BüscherJ W Dudenhausen
Sep 26, 2003·Pathology·Suzanne M Garland, Ellen D Bowman
Dec 17, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·M CetinkayaM Hacimustafaoğlu
Feb 1, 1994·Journal of Paediatrics and Child Health·S WagleS F Evans
Aug 1, 1997·The Pediatric Infectious Disease Journal·D L Jaye, K B Waites
Jul 21, 1995·Annals of the New York Academy of Sciences·K DrewsA Mackiewicz
Jul 6, 2000·Scandinavian Journal of Infectious Diseases·C PizziniV Fanos

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