Evaluation of captopril versus reserpine and frusemide in treating hypertensive children with acute post-streptococcal glomerulonephritis

Acta Paediatrica
M R MorsiA T Soliman


We have evaluated the effect of oral captopril versus a combination of oral reserpine and frusemide in the treatment of 20 children with post-streptococcal glomerulonephritis (APGN) with hypertension. Captopril produced a significantly greater reduction in systolic and diastolic blood pressure in both the standing and supine positions than reserpine + frusemide at 0.75, 1, 1.25, 8, 24, 48 and 72 h after initiating treatment. Neither postural hypotension nor reflex tachycardia accompanied the therapeutic effect of captopril. Blood urea, serum creatinine and creatinine clearance did not change significantly after therapy in either study group. Three days after initiating treatment, the 24 h urinary catecholamine output increased significantly in children who received captopril but did not change in children treated with frusemide and reserpine.


Feb 3, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ninoska VieraJesus Mosquera
Mar 22, 2005·Paediatric Drugs·Renee F RobinsonJohn D Mahan
Dec 8, 2009·Pediatric Clinics of North America·Gurmeet R Singh
Sep 23, 2014·Evidence-based Child Health : a Cochrane Review Journal·Swasti ChaturvediRulan Parekh
Feb 4, 2014·The Cochrane Database of Systematic Reviews·Swasti ChaturvediRulan Parekh
Feb 26, 2020·BMC Nephrology·Precil Diego Miranda de Menezes NevesViktoria Woronik

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