Evaluation of cardiac sympathetic neuronal integrity in diabetic patients using iodine-123 metaiodobenzylguanidine

European Journal of Nuclear Medicine
S J KimS G Lim

Abstract

Autonomic dysfunction is associated with increased mortality in diabetic patients. To evaluate the cardiac autonomic dysfunction in these patients, a prospective study was undertaken using iodine-123 metaiodobenzylguanidine (MIBG) single-photon emission tomography (SPET). The study groups consisted of ten diabetic patients with cardiac autonomic neuropathy (group I) and six without autonomic neuropathy (group II). Autonomic nervous function tests, thallium scan, radionuclide ventriculographic data including ejection fraction and wall motion study, and 24-h urine catecholamine levels were evaluated. 123I-MIBG SPET was performed at 30 min and 4h following injection of 3 mCi of 123I-MIBG in groups I and II and in normal subjects (n=4). On planar images, the heart to mediastinum (H/M) ratio was measured. Defect pattern and severity of MIBG uptake were qualitatively analysed on SPET. Compared with control subjects, diabetic patients had a reduced H/M ratio regardless of the presence of clinical autonomic neuropathy. There was no difference in H/M ratio between groups I and II. On SPET images, focal or diffuse defects were demonstrated in all patients in group I, and in five of the six patients in group II. The extent of defects tend...Continue Reading

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Citations

Apr 2, 2002·Annals of Nuclear Medicine·Shigeki NagamachiShigeru Matsukura
Oct 9, 2004·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Albert Flotats, Ignasi Carrió
Feb 9, 2006·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Nauman Mushtaq, Myron C Gerson
Jun 3, 2008·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Maureen M HennemanJeroen J Bax
Jul 25, 2008·Nature Clinical Practice. Cardiovascular Medicine·Jeanne M Link, James H Caldwell
Feb 25, 2017·Nuclear Medicine Communications·Harshvardhan RaoDnyanesh Tipre

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