Evaluation of cardiac troponin I immunoreaction in autopsy hearts: a possible marker of early myocardial infarction

Forensic Science International : Synergy
S H Hansen, K Rossen

Abstract

Postmortem diagnosis of early myocardial infarctions is an ever recurrent problem in pathology. In the present study we determined the troponin I expression in 46 autopsy hearts using an immunohistochemical technique. Troponin I has, as a specific cardiac muscle protein, become a widespread used marker in testing patients with acute chest pain. The hearts were divided into three groups based on the macroscopical findings: definite signs of infarction, possible signs of infarction and no signs of infarction. All 14 cases of definite myocardial infarction showed a well-defined area with loss of troponin I. Twenty-three of 24 cases of possible myocardial infarction also showed a well-defined area with loss of troponin I. None of the eight non-cardiac death controls showed loss of troponin I expression. The results suggest troponin I expression as a sensitive test in diagnosis of early myocardial infarction.

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Citations

Apr 10, 2003·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Michael C FishbeinFred S Apple
Jun 18, 2014·Forensic Science, Medicine, and Pathology·Mustafa Talip SenerAhmet Nezih Kok
Feb 9, 2016·Journal of Forensic and Legal Medicine·Çağlar Özdemirİbrahim İkizceli
Nov 8, 2008·Forensic Science International : Synergy·Frank WehnerMartin Manfred Schulz
Aug 11, 2007·International Journal of Cardiology·Nai-Nu LinYung-Tsung Chiu
Apr 28, 2004·Forensic Science International : Synergy·M D Pérez-CárcelesE Osuna
Nov 5, 2005·Forensic Science International : Synergy·Jan PeterJan Dressler
Sep 27, 2005·Forensic Science International : Synergy·Xiangzhi MengEnyin Wang
Sep 9, 2008·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Recai TuncaErhan Gokçe
Jun 4, 2008·The American Journal of Forensic Medicine and Pathology·Carlo P CampobassoMassimo F Colonna
Apr 18, 2019·Human & Experimental Toxicology·S M ZakiM M Abdelmoaty
Jun 20, 2015·Journal of Movement Disorders·Eun Joo Chung, Sang Jin Kim
Jan 25, 2018·International Journal of Legal Medicine·Aleksandra AljaknaSara Sabatasso
Aug 11, 2018·Applied Immunohistochemistry & Molecular Morphology : AIMM·Rosario Barranco, Francesco Ventura
Apr 16, 2002·The American Journal of Forensic Medicine and Pathology·Alfredo Ribeiro-SilvaMarcos A Rossi
Jan 11, 2020·Frontiers in Veterinary Science·Nakita CâmaraPedro Herráez
Nov 26, 2016·International Journal of Legal Medicine·Cristina MondelloElvira Ventura-Spagnolo
Feb 12, 2020·Applied Immunohistochemistry & Molecular Morphology : AIMM·Rosario Barranco, Francesco Ventura
May 8, 2018·International Journal of Legal Medicine·Cristina MondelloElvira Ventura Spagnolo
Jun 9, 2016·Open Access Macedonian Journal of Medical Sciences·Amany ShabaiekHebat Allah Amin

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