Evaluation of cartilage reconstruction by means of autologous chondrocyte versus periosteal graft transplantation: an animal study

Transplantation Proceedings
T TrzeciakP Lubiatowski

Abstract

Autologous chondrocyte transplantation (ACT) has been shown to heal cartilage defects under experimental and clinical conditions. However, the evaluation of successful transplantation still remains arbitrary and further research is required to establish objective criteria of treatment. The aim of the present study was to evaluate the criteria of successful ACT and to compare the results with those obtained following periosteal grafting (PG). Articular cartilage specimens were taken from the distal femur of 30 adolescent New Zealand rabbits and chondrocytes were obtained by collagenase digestion. The chondrocytes were identified by a functional assay, based on estimating procollagen type II mRNA by reverse-transcribed polymerase chain reaction. The cells cultured in vitro were transplanted under a periosteal flap into a full thickness defect (ICRS III(0)). The quality of the repaired tissue was evaluated macroscopically according to a modified scale of Brittberg et al, and microscopically according to O'Driscoll et al. For comparative purposes animals treated with PG were used. Cultured chondrocytes expressed procollagen type II and, upon transplantation into the defect, produced hyaline cartilage. To evaluate the results of tra...Continue Reading

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Citations

Mar 3, 2009·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Hongsen Chiang, Ching-Chuan Jiang
Oct 1, 2007·Reumatología clinica·Isaac Manuel Fuentes-BoqueteFrancisco Javier Blanco García
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Dec 23, 2008·Osteoarthritis and Cartilage·B J AhernT P Schaer
Sep 12, 2015·Annals of Biomedical Engineering·Wiktoria M SuchorskaTomasz Trzeciak
Oct 12, 2010·The Cochrane Database of Systematic Reviews·Haris S Vasiliadis, Jason Wasiak
Oct 11, 2013·Journal of Biomaterials Applications·M LebourgJ C Monllau

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Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

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