Evaluation of CD307a expression patterns during normal B-cell maturation and in B-cell malignancies by flow cytometry

Cytometry. Part B, Clinical Cytometry
Mariangeles AuatMaria Claudia Santos-Silva

Abstract

Flow cytometric immunophenotyping is deemed a fundamental tool for the diagnosis of B-cell neoplasms. Currently, the investigation of novel immunophenotypic markers has gained importance, as they can assist in the precise subclassification of B-cell malignancies by flow cytometry. Therefore, the purpose of the present study was to evaluate the expression of CD307a during normal B-cell maturation and in B-cell malignancies as well as to investigate its potential role in the differential diagnosis of these entities. CD307a expression was assessed by flow cytometry in normal precursor and mature B cells and in 115 samples collected from patients diagnosed with precursor and mature B-cell neoplasms. CD307a expression was compared between neoplastic and normal B cells. B-acute lymphoblastic leukemia cases exhibited minimal expression of CD307a, displaying a similar expression pattern to that of normal B-cell precursors. Mantle cell lymphoma (MCL) cases showed the lowest levels of CD307a among mature B-cell neoplasms. CD307a expression was statistically lower in MCL cases than in chronic B lymphocytic leukemia (CLL) and marginal zone lymphoma (MZL) cases. No statistical differences were observed between CD307a expression in neoplasti...Continue Reading

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Citations

Oct 1, 2019·Cytometry. Part B, Clinical Cytometry·Wolfgang Kern
Jul 21, 2020·Cytometry. Part B, Clinical Cytometry·Francesco Lanza, Enrico Maffini

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