Abstract
Drug resistance in Streptococcus pneumoniae, a frequent pathogen in community-acquired pneumonia, is increasing. Ceftaroline (active metabolite of ceftaroline fosamil) is a broad-spectrum intravenous cephalosporin with activity in vitro against drug-resistant Gram-positive organisms. We investigated ceftaroline at 600 mg every 12 h (q12h) (maximum concentration of the free, unbound drug in serum [fC(max)] is 15.2 μg/ml, and half-life [T(1/2)] is 2.5 h) versus ceftriaxone at 1 g q24h (fC(max) = 23 μg/ml, T(1/2) = 8 h) against six clinical S. pneumoniae isolates in a one-compartment in vitro pharmacokinetic/pharmacodynamic 96-h model (starting inoculum of 10(7) CFU/ml). Differences in CFU/ml (at 24 to 96 h) were evaluated by analysis of variance with a Tukey's post hoc test. Bactericidal activity was defined as a ≥ 3 log(10) CFU/ml decrease from the initial inoculum. Ceftaroline MICs were 0.06, 0.015, ≤ 0.008, 0.25, 0.25, and 0.5 μg/ml, and ceftriaxone MICs were 0.5, 0.25, 0.25, 4, 4, and 8 μg/ml for SP 1477, SP 669, SP 132, SP 211, SP 90, and SP 1466, respectively. Against the ceftaroline- and ceftriaxone-susceptible strain SP 1477, ceftaroline displayed sustained bactericidal activity (3 to 96 h, -5.49 log(10) CFU/ml) and was s...Continue Reading
References
Jan 1, 1985·The Journal of Antimicrobial Chemotherapy·J Blaser
Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·M S NiedermanUNKNOWN American Thoracic Society
Jul 23, 2002·The American Journal of Medicine·Roman PallaresFrancesc Gudiol
Dec 26, 2003·Pharmacotherapy·Raymond ChaMichael J Rybak
Mar 30, 2006·Antimicrobial Agents and Chemotherapy·D Andes, W A Craig
Jan 24, 2007·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·K Ge
May 29, 2007·The Pediatric Infectious Disease Journal·Stephen I PeltonWilliam P Hanage
Feb 1, 2008·Journal of Clinical Microbiology·Michael R JacobsCynthia G Whitney
Jul 16, 2008·Antimicrobial Agents and Chemotherapy·Yigong GeDaniel F Sahm
Aug 30, 2008·Antimicrobial Agents and Chemotherapy·Asunción FenollDavid Tarragó
Oct 31, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael R JacobsAnne R Windau
Nov 19, 2008·Antimicrobial Agents and Chemotherapy·Lesley McGeeKeith P Klugman
Feb 11, 2009·International Journal of Antimicrobial Agents·Ian MorrisseyRegina Janes
Apr 9, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Michael S Niederman
Aug 15, 2009·Diagnostic Microbiology and Infectious Disease·Laurent DortetUNKNOWN ORP Ile de France Ouest
Nov 3, 2009·Lancet·Tom van der Poll, Steven M Opal
Dec 2, 2009·The Pediatric Infectious Disease Journal·Chonnamet TechasaensiriGeorge H McCracken
Dec 18, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Niclas JohanssonJonas Hedlund
Jan 26, 2010·The Journal of Antimicrobial Chemotherapy·Hélène MoisanFrançois Malouin
Oct 20, 2010·Diagnostic Microbiology and Infectious Disease·Ronald N JonesDavid J Farrell
Nov 12, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Thomas M FileDirk Thye
Apr 26, 2011·The Journal of Antimicrobial Chemotherapy·Thomas M FileUNKNOWN FOCUS 1 investigators
Apr 26, 2011·The Journal of Antimicrobial Chemotherapy·Donald E LowUNKNOWN FOCUS 2 investigators
Apr 22, 2011·The Journal of Antimicrobial Chemotherapy·Ian A CritchleyDirk A Thye
May 18, 2011·Antimicrobial Agents and Chemotherapy·Delphine Croisier-BertinPascal Chavanet
Citations
Jun 27, 2013·Drugs·James E Frampton
Aug 8, 2012·Antimicrobial Agents and Chemotherapy·Lisa M AveryMichael J Rybak
Oct 28, 2014·Expert Opinion on Drug Metabolism & Toxicology·Andrew MerkerRobert C Glowacki
Jan 30, 2013·Diagnostic Microbiology and Infectious Disease·Andrew F ShorrH David Friedland
Oct 22, 2016·Drugs·Lesley J Scott
Jan 22, 2015·Antimicrobial Agents and Chemotherapy·George SakoulasVictor Nizet
Sep 26, 2020·European Journal of Clinical Pharmacology·Aaron J HeffernanJeffrey Lipman