Evaluation of cell affinity on poly(L-lactide) and poly(epsilon-caprolactone) blends and on PLLA-b-PCL diblock copolymer surfaces

Journal of Biomedical Materials Research. Part a
Diana Ajami-HenriquezPhilippe Dubois

Abstract

An evaluation of cell proliferation and adhesion on biocompatible film supports was performed. A series of films were compression molded from commercially available poly (L-lactide), PLLA, and poly(epsilon-caprolactone), PCL, and from their melt mixed blends (PLLA/PCL blends). These were compared with compression molded films of PLLA-b-PCL model diblock copolymers. The samples were analyzed by differential scanning calorimetry (DSC), contact angle measurements, and scanning force microscopy (SFM). Cell adhesion and proliferation were performed with monkey derived fibroblasts (VERO) and with osteoblastic cells obtained either enzymatically or from explants cultures of Sprague-Dawley rat calvaria. Migration studies were performed with bone explants of the same origin. The results obtained indicate that although all materials tested were suitable for the support of cellular growth, a PLLA-b-PCL diblock copolymer sample with 93% PLLA was significantly more efficient. This sample exhibited a unique surface morphology with long range ordered domains (of the order of 2-3 mum) of edge-on PLLA lamellae that can promote "cell contact guidance." The influence of other factors such as chemical composition, degree of crystallinity, and surf...Continue Reading

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Citations

Nov 1, 2011·AAPS PharmSciTech·Erde CanSeyda Bucak
Jun 8, 2011·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Maneesh JaiswalKrishan Gopal Jain
May 7, 2011·Journal of Tissue Engineering and Regenerative Medicine·Isaac A ChaimDiana Ajami
Oct 8, 2013·Materials Science & Engineering. C, Materials for Biological Applications·Hao-Yang MiLih-Sheng Turng
Aug 27, 2019·Angewandte Chemie·Viko LadeltaNikos Hadjichristidis
Jan 28, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·N GoonooD Jhurry
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Qiao XiaoLiumin He
Apr 18, 2020·ACS Applied Materials & Interfaces·Lorenzo VannozziLeonardo Ricotti
Oct 22, 2019·ACS Biomaterials Science & Engineering·Lindsay N Woodard, Melissa A Grunlan

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