PMID: 11337312May 19, 2001Paper

Evaluation of cell proliferation, apoptosis, and angiogenesis in transitional cell carcinoma of the renal pelvis and ureter

Urology
X ZhangI Takenaka

Abstract

To investigate cell proliferation, apoptosis, and angiogenesis and their roles in transitional cell carcinoma (TCC) of the renal pelvis and ureter. Formalin-fixed and paraffin-embedded tissue blocks from 42 patients with TCC of the renal pelvis and ureter were studied. Cell proliferation was assessed by Ki-67 immunostaining, and the proliferation index (PI) was expressed as a percentage of Ki-67-positive cells. Apoptosis was detected by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL), and the apoptotic index (AI) was expressed as a percentage of TUNEL positive cells. Angiogenesis was evaluated by CD31 immunostaining, and microvessel density (MVD) was expressed as the average of the microvessel count. The PI ranged from 5.9% to 48.0% (median 20.03%), AI from 1.0% to 4.2% (median 2.26%), and MVD from 16.0 to 146.0 (median 56.88) in TCC of the renal pelvis and ureter. Statistical analysis revealed close associations of both PI and MVD with tumor stage and of AI with tumor grade. Our study demonstrated a strong relationship between PI and MVD, but did not show associations of AI with PI or MVD in TCC of the renal pelvis and ureter. It is suggested that the high activity of tumor cell proliferati...Continue Reading

References

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Citations

Sep 28, 2004·Pathology Oncology Research : POR·Zahra AmirghofranZahra Malek-Hosseini
Nov 2, 2002·International Journal of Urology : Official Journal of the Japanese Urological Association·Xianghua ZhangYoshiyuki Kakehi
Jan 22, 2003·International Journal of Urology : Official Journal of the Japanese Urological Association·Toshiro OdaTaiji Tsukamoto
Nov 23, 2005·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Hyoung Jung KimYoun Wha Kim

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