Evaluation of cellulose xanthate-metal-tetracycline complexes as a polymeric antibacterial agent with prolonged antibacterial activity

Drug Delivery
Yunjin Jung, Young Mi Kim

Abstract

Cellulose xanthate-metal-tetracycline complexes (MCX-metal-Tc) were prepared and evaluated as a controlled release system for the antibiotics. Microcrystallized cellulose was chemically modified to cellulose xanthate (MCX). The amount of metal bound to MCX was 0.36 mmol Cu(II)/g MCX and 0.26 mmol Zn(II)/g MCX. Tetracycline (Tc) bound to MCX-metal chelates was 0.08 mmol/g MCX-Cu(II) and 0.04 mmol/g MCX-Zn(II). The Tc release from MCX-metal-Tc was greatly sustained compared with that from a mixture of cellulose/metal/Tc. Furthermore, MCX-metal-Tc manifested antibacterial activity that lasted for 7-22 days. These results suggest that MCX-metal-Tc is a polymeric antibacterial agent with prolonged antibacterial activity.

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Citations

May 13, 2014·Bioinorganic Chemistry and Applications·Savit AndotraSushil K Pandey
Jan 18, 2013·Drug Development and Industrial Pharmacy·Youn Taeg KimYoung Mi Kim
Apr 8, 2014·Acta Biomaterialia·Ourania-Menti GoudouriAldo R Boccaccini
Aug 4, 2011·The Journal of Antibiotics·Ping GaoGang Cheng

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