Evaluation of cerebral metabolism by ¹H-magnetic resonance spectroscopy for 4°C saline-induced therapeutic hypothermia in pig model of cardiac arrest

The American Journal of Emergency Medicine
Zhi-Yu SuMin Guo

Abstract

Previous studies have shown that therapeutic hypothermia could improve neurologic recovery when induced after cardiac arrest, but dynamic changes in cerebral metabolism have not been studied at low temperature. In this study, we aim to evaluate hypothermia-induced changes in pigs' cerebral metabolism by (1)H-magnetic resonance spectroscopy (¹H-MRS). Ten anesthetized Landrace (25-30 kg) pigs were randomized into 2 groups and subjected to 4 minutes of ventricular fibrillation, followed by cardiopulmonary resuscitation. The hypothermic group was given an infusion of 30 mL/kg of 4°C normal saline (NS) at an infusion rate of 1.33 mL/kg per minute starting after restoration of spontaneous circulation (ROSC), then 10 mL/kg per hour for 4 hours. The control group received the same infusion of room temperature NS. Core temperature and hemodynamic variables were monitored at baseline and repeatedly for 240 minutes after ROSC. The ¹H-MRS scans were obtained at baseline, 1 hour, and 3 hours after successful ROSC to observe the dynamic changes of cerebral metabolism at different temperatures. The mean reduction of temperature was 1.5°C ± 0.4°C in the hypothermic group. There was no difference in hemodynamic variables between groups. ¹H-MRS ...Continue Reading

References

Feb 22, 2002·The New England Journal of Medicine·UNKNOWN Hypothermia after Cardiac Arrest Study Group
May 26, 2004·Circulation·Benjamin S AbellaLance B Becker
Jun 10, 2006·Stroke; a Journal of Cerebral Circulation·Michael HolzerAnton N Laggner
Sep 14, 2006·Seminars in Neurology·Fred Rincon, Stephan A Mayer
Oct 6, 2007·Epilepsia·Girish K Hiremath, Imad M Najm
Oct 16, 2007·Resuscitation·Antti KämäräinenTom Silfvast
Mar 4, 2008·Resuscitation·Thomas UrayUNKNOWN Vienna Hypothermia After Cardiac Arrest (HACA) Study Group

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