Evaluation of cerebrospinal fluid lactic acid levels as an aid in differential diagnosis of bacterial and viral meningitis in adults.

Journal of Clinical Microbiology
R LanniganE V Haldane

Abstract

The level of lactic acid in cerebrospinal fluid has been suggested as a useful diagnostic parameter to differentiate between bacterial and viral meningitis, especially in patients partially treated before admission to hospital. A concentration of greater than or equal to 35 mg/dl, determined by either gas-liquid chromatography or an enzymatic method, has been considered in several studies to provide definite evidence of meningitis of bacterial origin, whereas a lower level indicates no bacterial involvement. Over the past 18 months, we have analyzed by the enzymatic method the lactate level in 493 spinal fluids submitted from 434 adult patients with various conditions involving the central nervous system. Fifty fluids had a lactate level of greater than 35 mg/dl, of which 19 were cases of infective meningitis of varying etiology. The 435 specimens with lactate levels within the range considered normal included three cases of infective meningitis, of which two were cryptococcal and one was bacterial. In this adult study, the lactate level in the cerebrospinal fluid did not provide unequivocal evidence of bacterial infection and did not provide assistance to any greater degree than the standard parameters of leukocyte count, prot...Continue Reading

References

Dec 1, 1977·Journal of Clinical Pathology·I R Ferguson, P V Tearle
Sep 1, 1977·The Journal of Pediatrics·G ControniW Khan
Aug 1, 1974·American Journal of Diseases of Children·R D BlandJ P Ries
Sep 1, 1960·Clinica Chimica Acta; International Journal of Clinical Chemistry·O MEULEMANS

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Citations

Jan 1, 1990·Intensive Care Medicine·B Genton, J P Berger
Jun 1, 1988·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·L LindquistG Axelsson
Jul 15, 2009·Rinshō shinkeigaku = Clinical neurology·Ken SakushimaHidenao Sasaki
Jun 1, 2013·Expert Opinion on Medical Diagnostics·Burke A Cunha
Feb 1, 1985·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section B, Microbiology·A LesterB Bruun
Jan 1, 1987·Journal of Clinical Pathology·D O Ho-Yen, D Carrington
Nov 18, 2020·British Journal of Clinical Pharmacology·Kris Oliver JalusicMichael Hessler
May 1, 1993·The Journal of Infection·P D CameronB M Ansari

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