Evaluation of Changes in Gut Microbiota in Patients with Crohn's Disease after Anti-Tnfα Treatment: Prospective Multicenter Observational Study

International Journal of Environmental Research and Public Health
Laura Sanchis-ArteroXavier Cortés-Rizo

Abstract

Background: Crohn's disease is believed to result from the interaction between genetic susceptibility, environmental factors and gut microbiota, leading to an aberrant immune response. The objectives of this study are to evaluate the qualitative and quantitative changes in the microbiota of patients with Crohn's disease after six months of anti-tumor-necrosis factor (anti-TNFα) (infliximab or adalimumab) treatment and to determine whether these changes lead to the recovery of normal microbiota when compared to a control group of healthy subjects. In addition, we will evaluate the potential role of the Faecalibacterium prausnitzii/Escherichia coli and Faecalibacterium prausnitzii/Clostridium coccoides ratios as indicators of therapeutic response to anti-TNFα drugs. Methods/Design: This prospective multicenter observational study will comprise a total of 88 subjects: 44 patients with Crohn's disease scheduled to start anti-TNFα treatment as described in the drug specifications to control the disease and 44 healthy individuals who share the same lifestyle and eating habits. The presence of inflammatory activity will be determined by the Harvey-Bradshaw index, analytical parameters in blood, including C-reactive protein, and fecal ...Continue Reading

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Citations

Aug 7, 2021·Biological Trace Element Research·Aleksandar StojsavljevićDragan Manojlović

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Methods Mentioned

BETA
imaging techniques
biopsies
surgical resection
PCR

Software Mentioned

ILLUMINA
STAMP
Microbiome
SPSS
GraphPad Prism
STAMP ( Statistical Analysis of Metagenomic Profiles )

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