Evaluation of changes in hepatic disposition of phenolsulfonphthalein, indocyanine green and fluorescein isothiocyanate-dextran at low temperatures using a rat liver perfusion system

The Journal of Pharmacy and Pharmacology
Hirotaka MiyamotoKoyo Nishida

Abstract

The aim of this study was to determine the factor changing the hepatic disposition of a drug during hypothermia using a rat liver perfusion system. The livers of male Wistar rats were perfused at 37, 32 or 28°C in the single-pass mode. Venous outflow dilution patterns and biliary excretion rate patterns of phenolsulfonphthalein (PSP), indocyanine green (ICG) and fluorescein isothiocyanate (FITC)-dextran (FD-4, MW 4400) after the injection of a bolus into the perfused rat liver were analysed based on statistical moment theory. The first-pass extraction ratio (E(h) ) of PSP was significantly decreased at 32 and 28°C compared with 37°C. The biliary recovery of PSP and its conjugate was decreased and the biliary excretion was kept at a high concentration and was prolonged by low perfusion temperatures. ICG was almost extracted by a single-pass through the liver even at 32 and 28°C. The biliary recovery of ICG was significantly decreased at low temperature. Although the distribution volume of FD-4 as a vascular reference was not changed by perfusion temperature, the E(h) of FD-4 was decreased at 28°C although not markedly. The change in hepatic disposition of a drug at low perfusion temperatures differed according to disposition pro...Continue Reading

References

Dec 1, 1978·Journal of Pharmacokinetics and Biopharmaceutics·K YamaokaT Uno
Sep 1, 1992·Journal of Pharmaceutical Sciences·R Mehvar, T L Shepard
Nov 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·L G Hart, L S Schanker
Jul 1, 1995·Journal of Pharmaceutical Sciences·R MehvarJ M Reynolds
Apr 1, 1995·Journal of Neurosurgical Anesthesiology·A Schubert
Feb 20, 1997·The New England Journal of Medicine·D W MarionS T DeKosky
May 22, 2001·Therapeutic Drug Monitoring·Y IidaA Asada
Jul 10, 2003·Lancet Neurology·Tom Skyhøj OlsenLars Peter Kammersgaard
Oct 1, 1958·Proceedings of the Society for Experimental Biology and Medicine·H O WHEELERJ I MELTZER
Jun 1, 1961·The American Journal of Physiology·G E MORTIMORE
Apr 1, 1960·The Journal of Clinical Investigation·G R CHERRICKC S DAVIDSON
Sep 11, 2007·Biological & Pharmaceutical Bulletin·Koyo NishidaToshiyuki Sakaeda

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Citations

Sep 4, 2020·Biological & Pharmaceutical Bulletin·Ayako TokunagaKoyo Nishida
Nov 4, 2016·Basic & Clinical Pharmacology & Toxicology·Fabien CusinCatherine M Pastor

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