Abstract
Improved survival of patients with childhood acute lymphoblastic leukemia (ALL) has drawn attention to the potential for late consequences of previous treatments among survivors, including metabolic syndrome. In this study, we evaluated changes in 3 parameters, namely, random blood glucose, body mass index (BMI), and Z score for BMI (Z-BMI), in children with ALL during chemotherapy and after completion of treatment. Patients newly diagnosed with ALL from January, 2005 to December, 2008 at Saint Mary's Hospital, The Catholic University of Korea, who completed treatment with chemotherapy only were included (n=107). Random glucose, BMI, and Z-BMI were recorded at 5 intervals: at diagnosis, before maintenance treatment, at completion of maintenance treatment, and 6 and 12 months after completion of maintenance treatment. Similar analyses were conducted on 2 subcohorts based on ALL risk groups. For random glucose, a paired comparison showed significantly lower levels at 12 months post-treatment compared to those at initial diagnosis (P<0.001) and before maintenance (P<0.001). The Z-BMI score was significantly higher before maintenance than at diagnosis (P<0.001), but decreased significantly at the end of treatment (P<0.001) and rema...Continue Reading
References
Dec 1, 1988·Diabetes·G M Reaven
Sep 1, 1997·Diabetes·J H PinkneyJ S Yudkin
Mar 29, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kevin C OeffingerUNKNOWN Childhood Cancer Survivor Study
Oct 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Katarina LinkEva Marie Erfurth
Sep 29, 2005·Journal of Pediatric Hematology/oncology·Maria KourtiFani Athanassiadou
Jan 30, 2007·Journal of the American College of Cardiology·Apoor S GamiVictor M Montori
Oct 17, 2008·Leukemia·J R RobersonS C Howard
Mar 5, 2009·Pediatric Blood & Cancer·Stefanie R LowasSuman Malempati
Apr 3, 2009·Pediatric Blood & Cancer·Stefanie LowasDaniel Marks
Aug 19, 2009·Pediatric Blood & Cancer·Janice S WithycombeNita L Seibel
Oct 24, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M van WaasM M van den Heuvel-Eibrink
Jan 7, 2010·Journal of Korean Medical Science·Jinkyung ParkTheresa A Nicklas
May 21, 2010·The Journal of Clinical Endocrinology and Metabolism·Cecilia FollinEva Marie Erfurth
Feb 1, 2011·Blood·Claire OudinGérard Michel
Citations
Oct 11, 2015·Leukemia & Lymphoma·Ernest K AmankwahPatrick A Brown
Mar 27, 2015·Pediatric Blood & Cancer·Fang Fang ZhangMichael J Kelly
Aug 11, 2016·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Jae Wook LeeHack-Ki Kim
Jun 9, 2017·Korean journal of pediatrics·Jae Wook Lee, Bin Cho
Jul 12, 2017·Annals of Pediatric Endocrinology & Metabolism·Hee Won Chueh, Jae Ho Yoo