Abstract
To investigate the dynamic changes of serum hepatitis B surface antigen (HBsAg) levels apportioned by the same hepatic parenchyma cell volume (HPCV), namely, hepatic cell quantities. Serum HBsAg levels were detected by electrochemiluminescence and serum HBsAg levels apportioned by the same HPCV were figured out according to the theory of sphere geometry. HBsAg levels were compared among different liver inflammation grades, as well as different hepatic fibrosis stages. In hepatitis B e antigen-negative chronic hepatitis B, serum HBsAg levels in liver histological inflammation grades 1-4 were 3.66 ± 0.40, 3.74 ± 0.35, 3.74 ± 0.26 and 3.71 ± 0.34 log10 COI (cut off index), respectively, and there were no differences before apportion (P = 0.640). Serum HBsAg levels apportioned by the same HPCV were 5.57 ± 0.62, 5.98 ± 0.65, 6.59 ± 0.50 and 6.81 ± 0.84 log10 COI, respectively, and there were significant differences after apportion (P < 0.001). Serum HBsAg levels in hepatic fibrosis stages I-IV were 3.66 ± 0.43, 3.75 ± 0.33, 3.71 ± 0.28 and 3.75 ± 0.26 log10 COI, respectively, and there were no differences before apportion (P = 0.513). Serum HBsAg levels apportioned by the same HPCV were 5.53 ± 0.66, 5.98 ± 0.53, 6.29 ± 0.46 and 7.06...Continue Reading
References
Oct 5, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S J Hadziyannis, D Vassilopoulos
Feb 7, 2002·Journal of Hepatology·Maurizia Rossana BrunettoFerruccio Bonino
Feb 15, 2005·Journal of Virology·Margaret ChenDavid R Milich
Dec 7, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Henry Lik-Yuen ChanJoseph Jao-Yiu Sung
Dec 31, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rami MoucariPatrick Marcellin
Feb 17, 2009·Lancet·Yun-Fan Liaw, Chia-Ming Chu
Apr 2, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Maurizia Rossana BrunettoPatrick Marcellin
Apr 29, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T Jake Liang
Jun 2, 2009·Gastroentérologie Clinique Et Biologique·UNKNOWN European Association For The Study Of The Liver
Mar 9, 2010·Journal of Hepatology·Tin NguyenStephen A Locarnini
Mar 9, 2010·Journal of Hepatology·Jerzy JaroszewiczMarkus Cornberg
May 11, 2010·Gastroenterology·Maurizia Rossana BrunettoFerruccio Bonino
Sep 11, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Milan J SonneveldHarry L A Janssen
Oct 12, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Karsten WursthornNikolai V Naoumov
Nov 26, 2010·Gastroentérologie Clinique Et Biologique·N Ben SlamaF Zoulim
Dec 7, 2010·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Ray M Merrill, Bradley D Hunter
Jul 29, 2011·Journal of Viral Hepatitis·W-M KeP-J Chen
Aug 23, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tai-Chung TsengJia-Horng Kao
Dec 20, 2011·Gut·Harry L A JanssenMaurizia R Brunetto
Jan 26, 2012·European Journal of Gastroenterology & Hepatology·Makoto AraiOsamu Yokosuka
Mar 17, 2012·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Mauro Viganò, Pietro Lampertico
Mar 29, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Stephen Locarnini, Scott Bowden