PMID: 16614481Apr 15, 2006Paper

Evaluation of chemopreventive action of Ginsenoside Rp1

BioFactors
Ashok KumarHiroshi Kimura

Abstract

We evaluated the chemopreventive properties of Ginsenoside Rp1 on 7,12-Dimethyl benz (a) anthracene (DMBA) skin papillomagenesis in Swiss albino mice. A significant reduction in values of tumor incidence, tumor burden, and cumulative number of papilloma was observed in mice treated orally with Ginsenoside Rp1 continuously at pre-, peri- and post-initiational stages of papillomagenesis as compared to the control group. Chemopreventive potential of Ginsenoside Rp1 was also observed on the skin metabolizing enzymes in Swiss albino mice. Ginsenoside Rp1 produced a significant elevation in the skin microsomal cytochrome p-450 and cytochrome b5, glutathione S-transferase (GST), reduced glutathione (GSH), glutathione peroxidase (GPX), glutathione reductase (GR), DT-diaphorase, superoxide dismutase (SOD) and catalase levels in the group of mice treated with Ginsenoside Rp1 for seven consecutive days. However, there was significant decrease in lipid peroxidation (LPO) level in Ginsenoside Rp1 treated group.

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Citations

Sep 2, 2008·Biological & Pharmaceutical Bulletin·Tae Yoon ParkHwan Mook Kim
Feb 13, 2016·Journal of Ginseng Research·Byong-Kyu ShinJeong Hill Park
Nov 8, 2014·Journal of Ginseng Research·Mi-Yeon KimJae Youl Cho
Oct 16, 2013·International Journal of Molecular Medicine·Joon-Seok ChoiJoydeb Kumar Kundu
Feb 2, 2021·Phytochemistry·Salar Hafez GhoranAmir Reza Jassbi

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