PMID: 6401766Feb 1, 1983Paper

Evaluation of chloride/bicarbonate. Exchange in the human colon in vivo

The Journal of Clinical Investigation
G R DavisJ S FORDTRAN

Abstract

During perfusion of a plasma-like solution, colonic absorption rate of chloride was much higher than the secretion rate of bicarbonate (34 vs. 3.5 meq/h, respectively). This might suggest that anion exchange (Cl/HCO3) accounts for only a small fraction of total chloride absorption. However, if the colon absorbs as well as secretes bicarbonate, this reasoning would underestimate the magnitude of the anion exchange. To see if the colon absorbs bicarbonate, we perfused a chloride-free solution (which would eliminate bicarbonate secretion via (Cl/HCO3 exchange) and found that the colon absorbed bicarbonate at a rate of 5.1 meq/h. Calculation of electrochemical gradients and measurement of luminal fluid PCO2 indicated that this bicarbonate absorption was mediated passively in response to electrical gradients, rather than via reversed Cl/HCO3 exchange or acid secretion. The combined results of the plasma-like and chloride-free perfusion experiments suggest Cl/HCO3 exchange at a rate of 8.6 meq/h (the sum of bicarbonate movements, 3.5 and 5.1 meq/h, observed in the two experiments). To obtain a second estimate under different experimental conditions, a choline chloride-choline bicarbonate (sodium-free) solution was perfused; with this...Continue Reading

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Citations

Mar 1, 1996·Pediatric Surgery International·U BeseghiG Monfort
Sep 1, 1987·Pflügers Archiv : European journal of physiology·G I Sandle, F McGlone
Sep 1, 1989·Pflügers Archiv : European journal of physiology·G I Sandle
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Jul 4, 2003·The Journal of Clinical Investigation·Michael A RussoJohn S Fordtran
Jun 22, 2011·International Journal of Radiation Biology·Kunzhong ZhangSadasivan Vidyasagar
Aug 27, 2011·Translational Research : the Journal of Laboratory and Clinical Medicine·Jin-Xia ZhuYing Xing
Aug 17, 2004·American Journal of Physiology. Cell Physiology·Sadasivan VidyasagarHenry J Binder
Jan 1, 1992·Veterinary Surgery : VS·M A McLoughlinJ G Hauptman
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Apr 3, 1996·Biochimica Et Biophysica Acta·R J MahajanP K Dudeja
Apr 1, 1996·Pediatric Clinics of North America·S A Acra, G K Ghishan

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