Evaluation of clinical and biochemical parameters in hepatocellular carcinoma: experience from an Indian center

Clinica Chimica Acta; International Journal of Clinical Chemistry
Nitin SainiY K Chawla

Abstract

Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver. Several etiologic factors including hepatitis viruses, alcohol and aflatoxin have been implicated in the pathogenesis of HCC. However, there is limited information regarding clinicopathological profile of HCC from the Indian subcontinent. Forty seven patients of HCC (M=43, F=4) diagnosed on the basis of history, clinical examination, imaging (USG, CT/MRI), alpha-fetoprotein (AFP) and by USG/CT guided FNAC, were included. Patients were screened for HBV, HCV and history of alcohol. Tumor size was assessed on imaging and UGI endoscopy for the presence of varices. The mean age was 53.4+/-14.6 y. Clinical presentation included anorexia in 32 (68%), abdominal pain in 28 (60%), loss of weight in 23 (49%), fever in 12 (26%), and jaundice in 6 (13%) patients. Twenty nine (62%) had underlying cirrhosis, diagnosed by ultrasound or CT. Seventeen percent had normal AFP (<10 ng/ml) and the remaining 83% had raised AFP [<10 ng/ml=7, 10-400 ng/ml=27, >400 ng/ml=8]. Thirteen patients (28%) were consuming alcohol in cirrhogenic doses and 10 (21%) were smokers. Fifty four percent were positive for HBsAg, 47% of these were also positive for HBeAg. Twenty seven perce...Continue Reading

References

Mar 1, 1982·Medicine·M C Kew, E W Geddes
Jan 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H OkaS Yamamoto
Oct 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y ShiratoriM Ohashi
Mar 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S TakanoM Omata
Jan 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P PaterliniC Bréchot
Oct 31, 1998·Journal of Viral Hepatitis·R IdilmanD H Van Thiel
Feb 24, 2001·Journal of Gastroenterology and Hepatology·I MericanD Z Xu
Jun 26, 2001·Journal of Gastroenterology and Hepatology·S K SarinB C Das

❮ Previous
Next ❯

Citations

Jun 5, 2013·PloS One·Christian M LangeUNKNOWN Swiss Hepatitis C Cohort Study Group
Nov 14, 2013·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Ajit SoodSuresh Kumar Sharma
Mar 11, 2015·Journal of Clinical and Experimental Hepatology·Ashish KumarUNKNOWN (The INASL Task-Force on Hepatocellular Carcinoma)
May 16, 2012·Journal of Medical Virology·Manash Pratim SarmaPremashis Kar
Sep 24, 2015·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Jayanthi SrirambhatlaTara Roshni Paul
Apr 7, 2018·Journal of Gastrointestinal Cancer·Ahmed M TahonDina Johar
Sep 25, 2017·Journal of Clinical and Translational Hepatology·Gautam Ray

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.

Adrenocortical Carcinoma

Hepatocellular carcinoma is the most common type of primary liver cancer and frequently occurs in individuals with chronic liver diseases like cirrhosis. Here is the latest research.