Evaluation of clonidine suppression and various provocation tests in the diagnosis of pheochromocytoma

Journal of Endocrinological Investigation
H KoshidaR Takeda

Abstract

Recent investigations have shown that the widely used clonidine suppression test is sometimes fallible for the diagnosis of pheochromocytoma. A comparative assessment was made of the following suppression and provocation tests, the clonidine suppression test, and the glucagon, metoclopramide, and naloxone provocation tests. The assessment was performed in 6 patients with pheochromocytoma and in 19 patients without pheochromocytoma who were initially suspected of harboring a tumor. BP response did not predict the presence of pheochromocytoma in any test. Plasma norepinephrine (NE) concentrations determined at 120 and 180 min after oral 150 micrograms of clonidine gave false negative results in 2 of the 5 patients with pheochromocytoma tested. Both plasma NE and epinephrine (E) concentrations were measured before and sequentially after each provocative agent. Neither NE nor E responded to 1 mg of glucagon iv in 2 of the 4 patients with pheochromocytoma tested. Determination of the peak level, peak increment, and % peak increment of NE and E following 10 mg of naloxone iv did not distinguish the two groups. The % peak increments of both NE and E in all 4 patients with pheochromocytoma given 5 mg of metoclopramide iv exceeded the m...Continue Reading

References

Dec 1, 1977·Acta Physiologica Scandinavica·H GalboJ J Holst
Nov 1, 1977·Southern Medical Journal·D A Cross, J S Meyer
Mar 1, 1986·The Journal of Clinical Endocrinology and Metabolism·M MannelliG Giusti
Jul 1, 1986·The Journal of Clinical Endocrinology and Metabolism·H C TaylorA H Anton
Nov 1, 1986·Acta Endocrinologica·L FavreM B Vallotton
Jul 1, 1985·AJR. American Journal of Roentgenology·S J McCorkell, N L Niles
Jun 1, 1985·American Journal of Surgery·M AbecassisJ E Kudlow
Jul 1, 1985·Acta Anaesthesiologica Scandinavica·O F SellevoldR Stenseth
Jul 1, 1985·Japanese Heart Journal·H KawabeT Saruta
Nov 15, 1984·The New England Journal of Medicine·E L Bravo, R W Gifford
Mar 17, 1983·The New England Journal of Medicine·M MannelliG Giusti
Oct 1, 1983·Metabolism: Clinical and Experimental·P D LevinsonA A Kowarski
Sep 16, 1982·The New England Journal of Medicine·J F Burris, L J D'Angelo
Sep 10, 1981·The New England Journal of Medicine·E L BravoR W Gifford

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Citations

Nov 2, 2007·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Graeme EisenhoferKarel Pacak

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