Evaluation of Coagulation Factors Activity in Different Types of Plasma Preparations

Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion
Ola Abdel Halim AfifiMaha Atwa Mohamed Ibrahim

Abstract

Fresh frozen plasma (FFP) is a crucial substitute therapy in management of bleeding; producing plasma from whole blood stored within 24 h offers operational flexibility and leukocyte filtration significantly reduce transfusion reactions, it is necessary to consider the impact of these plasma preparations on clotting factors activity. Total of 75 plasma samples collected from 25 blood donors distributed as 3 groups; FFP (Group A), leukocyte filtrated FFP (Group B) and plasma frozen within 24 h i.e. PF24 (Group C), for all samples prothrombin time (PT), INR, (APTT), Factors V, VII, VIII, IX levels and Fibrinogen were done, also comparing coagulation factors levels in FFP in different blood groups. There were significant difference between three groups in (PT), INR and (APTT): (P = 0.00). Concerning Factor VII: significant difference (P = 0.03) between the three groups, FFP had a significantly higher level of FVII compared to filtrated FFP (98.92 vs. 82.52%; P = 0.02), while no significant difference between FFP and PF24 was detected (P = 0.76). Factor VIII: had significant difference (P = 0.00) between the three groups, FFP and Filtrated FFP had no significant difference regarding level of FVIII (P = 0.72), but FFP had significan...Continue Reading

References

May 21, 1999·Transfusion·E M O'NeillC R Valeri
Jul 27, 2001·British Journal of Haematology·R CardiganL M Williamson
Nov 15, 2002·Transfusion·W H DzikC P Stowell
Jan 13, 2015·Experimental and Therapeutic Medicine·Dai-Yu LiHua Zhao
Jan 11, 2017·Journal of Blood Transfusion·Jason P AckerWilliam P Sheffield

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Citations

Jul 22, 2020·Transfusion·Tim W H RijnhoutRigo Hoencamp
Jan 28, 2021·Military Medicine·Elissa J FlaumenhaftSusanne Marschner

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