Evaluation of coal tar fractions for use in psoriasiform diseases using the mouse tail test. III. High boiling tar oil acids.

The British Journal of Dermatology
R Wrench, A Z Britten

Abstract

Twelve phenolic fractions of creosote and anthracene oils derived from a high temperature tar were applied in an ointment base to mouse tail skin. After treatment with the higher boiling acids, formerly parakeratotic scale areas underwent granular layer induction and 'basket-weave' keratin was produced. Changes in distribution of acid phosphatase and in horny layer fluorescence were consistent with the conversion to an orthokeratotic state. It is suggested that some of these phenols may be of value in the treatment of chronic psoriasis.

References

Jun 1, 1972·The British Journal of Dermatology·K LewinR A Ferrington
Nov 1, 1970·The British Journal of Dermatology·H Pinkus
Jan 1, 1964·Dermatologica·L J LOEWENTHAL
Jul 1, 1955·A.M.A. Archives of Dermatology·L H MARGOLISA FISCHER
Jan 1, 1949·The Medical Clinics of North America·S ROTHMAN, A L SHAPIRO

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Citations

Jan 1, 1990·Archives of Dermatological Research·K NaganoY Niitsu
Jan 1, 1985·Archives of Dermatological Research·P T BladonW J Cunliffe
Jan 1, 1980·Archives of Dermatological Research·R Wrench
Oct 6, 1997·Clinics in Dermatology·W P Arnold
Jan 1, 1976·The British Journal of Dermatology·R S Chapman, O A Finn
Nov 1, 1981·Clinical and Experimental Dermatology·J S Comaish
Dec 12, 2001·The British Journal of Dermatology·Y YoshidaK Fujimoto
Jan 1, 1988·The British Journal of Dermatology·M HofbauerM W Greaves

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