PMID: 11926554Apr 3, 2002Paper

Evaluation of coeliac disease serological markers in Down syndrome patients

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
M RumboR Villalobos

Abstract

The increased incidence of coeliac disease in patients with Down syndrome makes screening of coeliac disease in this population advisable. Evaluation of efficiency of different serological markers to detect coeliac disease in Down syndrome patients. A total of 56 Down syndrome patients (aged: 1-17 years) were included in study. Patients were evaluated for both IgG and IgA anti-transglutaminase antibodies and for anti-gliadin IgA and IgG antibodies using either purified omega-gliadin, wheat ethanol extract or commercial gliadin. Patients who had at least one positive result were evaluated for antiendomysium antibodies using either monkey oesophagus or human umbilical cord by indirect immunofluorescence. Coeliac disease was diagnosed by typical histological changes on duodenal mucosa. Increased levels of at least one anti-gliadin IgA and IgG antibody marker were found in 27 out of 56 cases (26 for IgG and 9 for IgA). 11/56 were positive for IgG anti-transglutaminase antibodies and two of them were also positive for IgA anti-transglutaminase antibodies and anti-endomysium antibodies. These two patients were finally diagnosed as coeliacs. Gliadin antigenic fractions employed produced differences in the performance of the anti-gliad...Continue Reading

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Citations

Jul 14, 2012·Indian Journal of Pediatrics·Abdus Sami BhatMadhulika Kabra
Jun 21, 2013·Alimentary Pharmacology & Therapeutics·J Y KangK Y Ho
Sep 27, 2005·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·F CataldoG Corsello
May 6, 2015·PloS One·Rafael Parra-MedinaJuan-Manuel Anaya
Feb 9, 2005·Journal of Pediatric Gastroenterology and Nutrition·Margherita Bonamico
Apr 27, 2007·Journal of Pediatric Gastroenterology and Nutrition·Hussein ShamalyRaanan Shamir
Aug 12, 2017·World Journal of Clinical Cases·Momcilo PavlovicMarko Bukurov

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