Evaluation of commercial screening tests and blot assays for the diagnosis of Lyme borreliosis

Diagnostic Microbiology and Infectious Disease
Laurent BussonOlivier Vandenberg

Abstract

The performance of 4 screening tests and 10 blot assays for the serologic diagnosis of Lyme borreliosis in a Belgian population was evaluated. A total of 196 sera were tested: 36 Lyme borreliosis at different stages of the disease, 50 healthy blood donors, and 110 representing various clinical circumstances. The DiaSorin Liaison and Euroimmun Anti-Borrelia screening tests were evaluated. The tested blot assays were Virotech Borrelia LINE tests WE222, WE225, and WE224, as well as Mikrogen recomLine Borrelia and Viramed ViraStripe. The specificity of IgG was acceptable for the different assays. For IgM, DiaSorin Liaison Borrelia IgM Quant, Mikrogen recomLine, and Viramed ViraStripe lacked specificity. Interestingly, a higher rate of falsely reactive samples was observed in the group of patients suffering from malaria. Serological diagnosis of Lyme borreliosis remains challenging; assays should be evaluated in the population where they are intended to be used.

References

Jan 1, 1993·Diagnostic Microbiology and Infectious Disease·S Sayahtaheri-AltaieH P Dalton
Oct 17, 1996·The New England Journal of Medicine·J A Newton, P V Pepper
Oct 12, 1999·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·H A GoossensM K Nohlmans
Feb 15, 2001·Diagnostic Microbiology and Infectious Disease·J L Backhouse, S I Nesteroff
Feb 5, 2002·Journal of Clinical Microbiology·Kurt D Reed
Dec 21, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P BrouquiUNKNOWN European Network for Surveillance of Tick-Borne Diseases
Jul 16, 2005·Clinical Microbiology Reviews·Maria E Aguero-RosenfeldGary P Wormser
Feb 3, 2007·FEMS Immunology and Medical Microbiology·Bettina WilskeUlrike Schulte-Spechtel
Jul 23, 2009·Current Opinion in Infectious Diseases·Christer LarssonSven Bergström
Nov 6, 2009·Journal of Applied Microbiology·S J Cutler
Feb 6, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·G StanekJ Gray
Jan 29, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C W AngT Herremans
Mar 19, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·G Stanek, M Reiter

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Citations

Aug 10, 2013·Folia Microbiologica·D PíchaZ Blechová
Aug 27, 2014·Médecine et maladies infectieuses·E TwizeyimanaS J De Martino
Jul 31, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·P W SmitO Vapalahti
Feb 5, 2019·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Ulrike Hauser
Oct 12, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Tizza P ZomerBarend van Kooten
Jan 29, 2021·Clinical Microbiology Reviews·John A Branda, Allen C Steere
Jan 8, 2021·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Henrik Hillerdal, Anna J Henningsson
Apr 23, 2021·Journal of Clinical Microbiology·M E (Ewoud) BaarsmaJoppe W Hovius

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