Evaluation of complete Freund's adjuvant-induced arthritis in a Wistar rat model. Comparison of thermography and histopathology

Zeitschrift für Rheumatologie
U SnekhalathaM Menaka

Abstract

The aim of this study was to evaluate the progression of arthritis in a complete Freund's adjuvant (CFA)-induced Wistar rat model and to monitor inflammatory arthritis activity using thermal imaging compared with histopathology. Fifteen adult male Wistar rats were studied in an adjuvant-induced arthritis model by the injection of complete Freund's adjuvant in the right hind limb and right forelimb, respectively, with the left limbs used as controls. Thermal image analysis based on skin temperature measurement, radiographic analysis based on erosion, limb circumference measurement, and histopathological evaluation were performed. The average skin temperature difference on the arthritis-induced side and control for both the forelimb and hind limb were found to be 1.09 °C and 0.98 °C, respectively. Pearson correlation analysis revealed that skin surface temperature was positively correlated with the arthritis severity score (forelimb: r = 0.64, hind limb: r = 0.66, p < 0.05).A significant correlation also existed between thermal imaging temperature and visual scoring of X-ray (forelimb: r = 0.56, hind limb: r = 0.67, p < 0.05). Thermal imaging measurements correlated with arthritis severity score, radiological score, and ankle dia...Continue Reading

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Citations

Jul 15, 2015·Immunopharmacology and Immunotoxicology·Modesto Gómez LópezRafael Campos Rodríguez
Jan 24, 2018·Autoimmunity·Sahar Sobhy Abd-ElhalemNashwa Ahmed El-Shinnawy
Apr 2, 2019·Drug Development and Industrial Pharmacy·Shweta PandeySushama Talegaonkar
Feb 21, 2019·The Journal of Pharmacy and Pharmacology·Laura MicheliLorenzo Di Cesare Mannelli
Apr 21, 2019·International Journal of Molecular Sciences·Laura MicheliLorenzo Di Cesare Mannelli
Feb 18, 2017·Immunopharmacology and Immunotoxicology·Yasmin Moustafa AhmedAli Ahmed Abo-Saif
Jun 22, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tianyao ZhengZhen Ou-Yang
Jun 21, 2021·International Immunopharmacology·Ming JingWenyu Xin

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