Evaluation of constipation in older adults: radioopaque markers (ROMs) versus wireless motility capsule (WMC)

Archives of Gerontology and Geriatrics
S S C RaoK Mysore

Abstract

There is scarce information regarding assessment of constipation in older subjects. We examined regional and whole-gut transit time (WGTT) with wireless motility capsule (WMC) and compared this with radioopaque markers (ROM) transit. 39 constipated and 11 healthy older subjects (≥ 65 years) ingested a ROM capsule and WMC, wore a data receiver and kept stool diaries for 5 days. WMC recordings were analyzed for colonic transit time (CTT), WGTT and gastric emptying time (GET). Radiographs obtained on day 5 assessed ROM transit. Results for each device were compared. The CTT (p = <0.0001), WGTT (p = <0.001) and GET (p = <0.04) as measured by WMC were all slower in constipated subjects compared to healthy subjects. ROM colonic transit was also slower (p = <0.007) in constipated compared to healthy subjects. The diagnostic utility for identifying subjects with constipation as assessed by receiver operating characteristics were similar; 0.85 (WMC) versus 0.73 (ROM). Device agreement for slow colonic transit was 88% with good correlation between WMC and ROM (CTT r=0.718, p=0.0001, WGTT r=0.693, p=0.0001). Slow transit constipation was identified in 28% with ROM and 32% with WMC. No adverse events were recorded. WMC is a safe and useful...Continue Reading

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Citations

Nov 26, 2013·Clinics in Geriatric Medicine·Siegfried W B Yu, Satish S C Rao
Aug 25, 2015·Computers in Biology and Medicine·M KeuchelA Koulaouzidis
May 5, 2016·Gastroenterology·Satish Sc RaoArnold Wald
Jun 9, 2016·Journal of Neurogastroenterology and Motility·Satish S C Rao, Tanisa Patcharatrakul
Jun 3, 2014·Expert Review of Gastroenterology & Hepatology·William L Hasler
Oct 21, 2017·Gut and Liver·Tanisa Patcharatrakul, Satish S C Rao
Sep 2, 2016·F1000Research·Klaus BielefeldtSalman Nusrat
May 24, 2019·The Journal of Veterinary Medical Science·Riki SiswandiNariaki Nonaka
Feb 26, 2016·Current Gastroenterology Reports·Richard J Saad
Nov 25, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Mark RadeticMichael Cline
Nov 14, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Leonel RodriguezSamuel Nurko

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