Evaluation of continuous infusion of lidocaine on gastrointestinal tract function in normal horses

Veterinary Surgery : VS
Karen E RusieckiJack R Snyder

Abstract

To determine the effect of continuous infusion of lidocaine on fecal transit time in normal horses. Experimental randomized cross-over study. Healthy horses (n=6). Barium-filled microspheres were administered to horses by nasogastric intubation and feces were collected every 2 hours for 4 days. A bolus of 2% lidocaine (1.3 mg/kg) was administered randomly, followed by a continuous infusion of lidocaine (0.05 mg/kg/min) for 3 days or an equivalent volume of saline. The washout period was 10 days. Variables assessed included defecation frequency, weight of feces produced, intestinal transit time (number of microspheres observed on radiographs), fecal moisture content, borborygmus score, heart and respiratory rate, and signs of lidocaine toxicity (e.g., ataxia, CNS depression). During the first 24 hours of lidocaine administration, mean (+/-SD) fecal output (10.8+/-6.9 kg) was decreased compared with controls (15+/-4.9 kg). Mean (+/-SEM) time for passing 50% of the barium-filled microspheres was shorter in controls (42+/-1.13 hours) compared with the lidocaine group (50+/-1.32 hours). Continuous infusion of lidocaine increases the transit time of feces in normal horses. Clinicians need to be aware of the effects of using a continu...Continue Reading

References

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Citations

Jul 26, 2011·Journal of Veterinary Internal Medicine·J R ElfenbeinL C Sanchez
Jul 25, 2013·American Journal of Veterinary Research·Jorge E NietoJack R Snyder
Jul 8, 2009·The Veterinary Clinics of North America. Equine Practice·Gal Kelmer
Mar 22, 2014·Equine Veterinary Journal·L C Sanchez, S A Robertson
Feb 7, 2018·Equine Veterinary Journal·D E Freeman
Dec 28, 2017·Equine Veterinary Journal·Z M LisowskiN P H Hudson
Nov 21, 2017·Journal of the American Veterinary Medical Association·Rita F WehrmanHeather L Chandler
Feb 7, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Moorkath NandakumaranMajed Al-Shammari

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